TGF beta Receptor 1/TGFBR1 Antibody (B-7): sc-518045

TGFβ RI Antibody (B-7) is a mouse monoclonal IgG1 antibody that detects TGFβ RI in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TGFβ RI, a 503 amino acid single-pass type I membrane protein, plays a crucial role in the TGFβ signaling pathway by forming a receptor complex with TGFβ RII, which is essential for mediating the growth-inhibitory effects of TGFβ. TGFβ RI′s location in the cell membrane enables effective transduction of extracellular signals into the cell, influencing various cellular processes such as proliferation, differentiation, and apoptosis. Defects in the gene encoding TGFβ RI have been linked to serious conditions such as aortic aneurysm familial thoracic type 5 and Loeys-Dietz syndrome, highlighting TGFβ RI′s critical role in maintaining vascular integrity and normal developmental processes. Anti-TGFβ RI antibody (B-7) serves as an invaluable tool for researchers studying TGFβ signaling and its implications in various diseases, providing insights into the molecular mechanisms underlying these critical biological processes.

The preferred TGF beta Receptor 1/TGFBR1 antibody is TGF beta Receptor 1/TGFBR1 Antibody (C-12): sc-518086.