TFPI-2 Antibody (C-3): sc-48369

TFPI-2 Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects TFPI-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TFPI-2, also known as placental protein 5, is a glycoprotein that plays a crucial role in regulating blood coagulation by inhibiting the extrinsic pathway, thereby preventing excessive clot formation. TFPI-2 is primarily located in the extracellular matrix and is secreted by various cell types, including endothelial cells and trophoblasts, which is significant because TFPI-2′s presence in the extracellular environment allows interaction with and modulation of coagulation factors, particularly factor Xa and the tissue factor-factor VIIa complex. TFPI-2′s ability to inhibit these components is vital for maintaining hemostatic balance and preventing thrombotic disorders. Additionally, TFPI-2 undergoes post-translational modifications, such as glycosylation, which can influence stability, activity, and interactions with other proteins, further underscoring TFPI-2′s importance in the coagulation cascade and potential implications in various pathological conditions. Anti-TFPI-2 antibody (C-3) is an essential tool for researchers studying coagulation processes and related diseases, providing reliable detection and characterization of this critical protein.

The preferred TFPI-2 antibody is TFPI-2 Antibody (B-7): sc-48380.