TFIID/TATA Binding Protein/TBP Antibody (1TBP18): sc-56795

TFIID Antibody (1TBP18) is a mouse monoclonal IgG1 antibody that detects TFIID in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). TFIID plays a crucial role in the initiation of transcription by RNA polymerase II, serving as a key component of the pre-initiation complex that assembles at the core promoter region of protein-coding genes. The TATA-binding protein (TBP), a subunit of TFIID, is essential for recognizing and binding to the TATA box, a conserved DNA sequence located approximately 25-30 base pairs upstream of the transcription start site. This interaction facilitates the recruitment of additional transcription factors and RNA polymerase II, ultimately leading to the formation of a functional transcription complex. The structural integrity of TFIID, particularly the highly-conserved 180 amino acid C-terminal domain of TBP, is critical for its function, as any alterations can disrupt the transcriptional machinery and affect gene expression. Anti-TFIID antibody (1TBP18) is an invaluable tool for researchers studying transcription regulation and its implications in various biological processes and diseases.

The preferred TFIID/TATA Binding Protein/TBP antibody is TFIID/TATA Binding Protein/TBP Antibody (58C9): sc-421.