TET3 Antibody (D-7): sc-518126
- TET3 Antibody (D-7) is a mouse monoclonal IgM κ TET3 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 80-99 of TET3 of human origin
- recommended for detection of TET3 of human origin by WB, IP, IF and ELISA
- Anti-TET3 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TET3 Antibody (D-7) for WB applications. This reagent is now offered in a bundle with TET3 Antibody (D-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
TET3 Antibody (D-7) is a mouse monoclonal IgM antibody that detects TET3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TET3 (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TET3, or tet oncogene family member 3, is a 1,660 amino acid protein that plays a crucial role in DNA demethylation, a process essential for regulating gene expression and maintaining cellular identity. TET3 function is particularly important in development and differentiation, as aberrations in DNA methylation patterns can lead to various diseases, including cancer. TET3 is expressed in several tissues, including the fetal and adult brain, muscle, colon, and adrenal gland, and exists in multiple alternatively spliced isoforms, which may contribute to diverse functional roles. TET3 gene is located on human chromosome 2, a region that contains over 1,400 genes and represents nearly 8% of the human genome, highlighting the complexity and significance of genetic regulation in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TET3 Antibody (D-7) References:
- ABCA12 is the major harlequin ichthyosis gene. | Thomas, AC., et al. 2006. J Invest Dermatol. 126: 2408-13. PMID: 16902423
- Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome. | Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
- Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis. | Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
- Alström syndrome. | Marshall, JD., et al. 2007. Eur J Hum Genet. 15: 1193-202. PMID: 17940554
- Origin of human chromosome 2: an ancestral telomere-telomere fusion. | IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367
- Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. | Abdel-Wahab, O., et al. 2009. Blood. 114: 144-7. PMID: 19420352
- Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis. | Cao, T., et al. 2019. J Ovarian Res. 12: 101. PMID: 31656201
- Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency. | Chen, B., et al. 2022. Nature. 605: 761-766. PMID: 35585240
- TET3 plays a critical role in white adipose development and diet-induced remodeling. | Jung, BC., et al. 2023. Cell Rep. 42: 113196. PMID: 37777963
- Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. | Liu, B., et al. 2024. Diabetologia. 67: 724-737. PMID: 38216792
- Epigenetic Regulatory Axis MIR22-TET3-MTRNR2L2 Represses Fibroblast-Like Synoviocyte-Mediated Inflammation in Rheumatoid Arthritis. | Fang, Y., et al. 2024. Arthritis Rheumatol. 76: 845-856. PMID: 38221658
- TET3-overexpressing macrophages promote endometriosis. | Lv, H., et al. 2024. J Clin Invest. 134: PMID: 39141428
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TET3 Antibody (D-7) | sc-518126 | 200 µg/ml | $322.00 | |||
TET3 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-551125 | 200 µg Ab; 40 µg BP | $361.00 | |||
TET3 Antibody (D-7) AC | sc-518126 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TET3 Antibody (D-7) HRP | sc-518126 HRP | 200 µg/ml | $322.00 | |||
TET3 Antibody (D-7) FITC | sc-518126 FITC | 200 µg/ml | $336.00 | |||
TET3 Antibody (D-7) PE | sc-518126 PE | 200 µg/ml | $349.00 | |||
TET3 Antibody (D-7) Alexa Fluor® 488 | sc-518126 AF488 | 200 µg/ml | $364.00 | |||
TET3 Antibody (D-7) Alexa Fluor® 546 | sc-518126 AF546 | 200 µg/ml | $364.00 | |||
TET3 Antibody (D-7) Alexa Fluor® 594 | sc-518126 AF594 | 200 µg/ml | $364.00 | |||
TET3 Antibody (D-7) Alexa Fluor® 647 | sc-518126 AF647 | 200 µg/ml | $364.00 | |||
TET3 Antibody (D-7) Alexa Fluor® 680 | sc-518126 AF680 | 200 µg/ml | $364.00 | |||
TET3 Antibody (D-7) Alexa Fluor® 790 | sc-518126 AF790 | 200 µg/ml | $364.00 |