Testisin Antibody (A-11): sc-390317

Testisin Antibody (A-11) is a mouse monoclonal IgM antibody that detects Testisin protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Testisin antibody (A-11) is available as the non-conjugated form. Testisin, also known as ESP-1, is a testis-specific serine protease that plays a crucial role in spermatogenesis and fertilization, making Testisin essential for male fertility. Beyond reproductive functions, Testisin is implicated in various biological processes, including capillary morphogenesis and angiogenesis, highlighting potential regulatory roles in these systems. Testisin is primarily localized in the cytoplasm and on the plasma membrane of round and elongating spermatids, which is vital for sperm development. The testisin gene is located on the short arm of human chromosome 16 (16p13.3) and undergoes alternative pre-mRNA splicing to produce two distinct isoforms. While testisin gene is expressed in normal testis cells, testisin expression is absent in testis tumor cell lines, yet present in ovarian carcinoma, suggesting that expression changes may contribute to testicular and ovarian tumor development and progression.

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Testisin Antibody (A-11) References:

1. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors.  |  Hooper, JD., et al. 1999. Cancer Res. 59: 3199-205. PMID: 10397266
2. Localization, expression and genomic structure of the gene encoding the human serine protease testisin.  |  Hooper, JD., et al. 2000. Biochim Biophys Acta. 1492: 63-71. PMID: 11004480
3. Overexpression of testisin, a serine protease expressed by testicular germ cells, in epithelial ovarian tumor cells.  |  Shigemasa, K., et al. 2000. J Soc Gynecol Investig. 7: 358-62. PMID: 11111072
4. Organization and chromosomal localization of the murine Testisin gene encoding a serine protease temporally expressed during spermatogenesis.  |  Scarman, AL., et al. 2001. Eur J Biochem. 268: 1250-8. PMID: 11231276
5. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis.  |  Aimes, RT., et al. 2003. Thromb Haemost. 89: 561-72. PMID: 12624642
6. Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the rat.  |  Nakamura, Y., et al. 2003. J Med Invest. 50: 78-86. PMID: 12630572

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Testisin Antibody (A-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Testisin Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Testisin Antibody (A-11) Specifications

Alternate Product Name: Testisin

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 111-149

Epitope Target: Testisin

Epitope Species: mouse

Product Reactivity/Detection: precursor and mature Testisin

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Testisin Antibody (A-11): P: Blocking Peptide