Testisin Inhibitors
Testisin Inhibitors are a class of compounds that can directly or indirectly decrease the functional activity of Testisin, a serine protease. Serine protease inhibitors such as AEBSF, Leupeptin, PMSF, Benzamidine, and Aprotinin act by targeting the serine residues at the active site of Testisin, leading to direct inhibition of its proteolytic function. These inhibitors bind to the active site of the enzyme, thereby preventing substrate binding and subsequent proteolytic activity. In the case of irreversible inhibitors like PMSF, the inhibition is permanent and results in a complete loss of enzyme function.
Other inhibitors may target residues other than serine within the active site of Testisin. For instance, E-64, an inhibitor of cysteine proteases, and alkylating agents such as Iodoacetamide and N-Ethylmaleimide, can target the cysteine residue within the active site of Testisin, leading to its inhibition. On the other hand, Pepstatin A, an inhibitor of aspartic proteases, might target aspartic acid residues inTestisin, reducing its enzymatic activity. Even though Testisin does not directly require metal ions for its function, the activity of Testisin can still be indirectly affected by chelating agents like EDTA, Phenanthroline, and 1,10-Phenanthroline.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
AEBSF is a serine protease inhibitor that specifically targets serine residues at the active site of proteases. Testisin, being a serine protease, could be directly inhibited by AEBSF, leading to diminished proteolytic activity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is a potent inhibitor of serine and cysteine proteases. By targeting the active sites of these enzymes, leupeptin can inhibit Testisin, reducing its proteolytic function. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 is a potent inhibitor of cysteine proteases. While Testisin is primarily a serine protease, it possesses a cysteine residue within its active site that could potentially be targeted by E-64, causing its inhibition. | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | $50.00 $697.00 | 92 | |
PMSF is a serine protease inhibitor that irreversibly inhibits the active site of serine proteases. By targeting the serine residues at Testisin's active site, PMSF could inhibit its proteolytic function. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
Iodoacetamide is an alkylating agent that can modify cysteine residues. It could potentially inhibit Testisin by alkylating the cysteine residue within its active site, causing a loss of proteolytic activity. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide is a sulfhydryl-reactive alkylating agent that can modify cysteine residues. It could potentially inhibit Testisin by alkylating the cysteine residue within its active site, causing a loss of proteolytic activity. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
Phenanthroline is a chelating agent that sequesters metal ions. While Testisin does not require metal ions for its activity, the sequestration of metal ions could indirectly affect cellular processes that Testisin is involved in, leading to its functional inhibition. | ||||||
Benzamidine | 618-39-3 | sc-233933 | 10 g | $292.00 | 1 | |
Benzamidine is an inhibitor of serine proteases that acts by binding to the active site. It could directly inhibit Testisin by binding to the serine residue in its active site, reducing its proteolytic activity. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
Aprotinin is a potent protease inhibitor that can inhibit a range of serine proteases. By binding to the active site, it can directly inhibit Testisin, leading to a reduction in its proteolytic function. | ||||||