TES Antibody (G-9): sc-271184

TES Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects TES protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TES (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TES protein, also known as Testin, plays a crucial role in cellular adhesion and signaling, as TES localizes at cell-cell contacts and along actin stress fibers. This localization is vital for maintaining tissue architecture and regulating cell motility, which is particularly important in processes such as wound healing and cancer metastasis. TES interacts with several cytoskeletal proteins, including Zyxin, Mena, VASP, Talin, and Actin, and TES′s ability to associate with α-actinin, paxillin, and Zyxin is influenced by conformational state. Notably, TES contains three LIM zinc-binding domains, which are essential for TES′s function as a potential tumor suppressor. Overexpression of TES has been linked to increased cell spreading and decreased cell motility, highlighting TES′s significance in cellular dynamics and tumor biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TES Antibody (G-9) References:

1. TES is a novel focal adhesion protein with a role in cell spreading.  |  Coutts, AS., et al. 2003. J Cell Sci. 116: 897-906. PMID: 12571287
2. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.  |  Garvalov, BK., et al. 2003. J Cell Biol. 161: 33-9. PMID: 12695497
3. Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene.  |  Chêne, L., et al. 2004. Int J Cancer. 111: 798-804. PMID: 15252854
4. AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts.  |  Rotter, B., et al. 2005. Biochem J. 388: 631-8. PMID: 15656790
5. RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisation.  |  Griffith, E., et al. 2005. Cell Motil Cytoskeleton. 60: 140-52. PMID: 15662727
6. Transcranial electric stimulation (tES) and NeuroImaging: the state-of-the-art, new insights and prospects in basic and clinical neuroscience.  |  Soekadar, SR., et al. 2016. Neuroimage. 140: 1-3. PMID: 27633745
7. TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.  |  Wang, DD., et al. 2019. Cancer Commun (Lond). 39: 3. PMID: 30728082
8. Effectiveness of TES and rTMS for the Treatment of Insomnia: Meta-Analysis and Meta-Regression of Randomized Sham-Controlled Trials.  |  Ma, H., et al. 2021. Front Psychiatry. 12: 744475. PMID: 34744835
9. Immunohistochemistry Study of OY-TES-1 Location in Fetal and Adult Human Tissues.  |  Fu, J., et al. 2022. J Healthc Eng. 2022: 7052830. PMID: 35463688
10. Online closed-loop real-time tES-fMRI for brain modulation: A technical report.  |  Mulyana, B., et al. 2022. Brain Behav. 12: e2667. PMID: 36134450
11. Acute transcutaneous electrical stimulation (TES) augments esophageal contractility in patients with weak peristalsis.  |  Amaris, MA., et al. 2023. Clin Transplant. 37: e15005. PMID: 37144846
12. Towards targeting transposable elements for cancer therapy.  |  Liang, Y., et al. 2024. Nat Rev Cancer. 24: 123-140. PMID: 38228901

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TES Antibody (G-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TES Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TES Antibody (G-9) Specifications

Alternate Product Name: TES

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 235-274

Epitope Target: TES

Epitope Species: human

Product Reactivity/Detection: TES

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TES Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin