TEM7 Antibody (4H260): sc-73135

TEM7 Antibody (4H260) is a mouse monoclonal IgG1 antibody that detects TEM7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-TEM7 antibody (4H260) is available as the non-conjugated format. TEM7 protein, also known as plexin domain containing 1, plays a crucial role in tumor angiogenesis and neoangiogenesis, showing high expression in endothelial cells of tumors and neurons. TEM7 is involved in blood vessel formation regulation, making TEM7 a significant target for antiangiogenic therapies aimed at inhibiting tumor growth. TEM7 primarily localizes to the cell surface membrane, interacting with various signaling pathways that promote endothelial cell proliferation and migration. Understanding TEM7 function and localization is essential for developing therapeutic strategies that can effectively disrupt tumor vascularization, thereby limiting nutrient and oxygen supply to rapidly growing tumors. TEM7 (4H260) antibody serves as an invaluable tool for researchers investigating tumor angiogenesis mechanisms and potential targeted cancer therapies.

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TEM7 Antibody (4H260) References:

1. Cell surface tumor endothelial markers are conserved in mice and humans.  |  Carson-Walter, EB., et al. 2001. Cancer Res. 61: 6649-55. PMID: 11559528
2. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.  |  Yamamoto, Y., et al. 2004. Oncogene. 23: 3889-97. PMID: 15021905
3. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.  |  Nanda, A., et al. 2004. Cancer Res. 64: 8507-11. PMID: 15574754
4. Modulation of tumor endothelial cell marker 7 expression during endothelial cell capillary morphogenesis.  |  Wang, XQ., et al. 2005. Microvasc Res. 70: 189-97. PMID: 16202431
5. Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo.  |  Lee, HK., et al. 2006. FEBS Lett. 580: 2253-7. PMID: 16574105
6. Expression of tumor endothelial marker 7 mRNA and protein in the dorsal root ganglion neurons of the rat.  |  Lee, HK., et al. 2006. Neurosci Lett. 402: 71-5. PMID: 16707219
7. PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium.  |  Beaty, RM., et al. 2007. J Neurooncol. 81: 241-8. PMID: 17031559
8. TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy.  |  Yamaji, Y., et al. 2008. Invest Ophthalmol Vis Sci. 49: 3151-7. PMID: 18316703
9. TEM7 (PLXDC1), a key prognostic predictor for resectable gastric cancer, promotes cancer cell migration and invasion.  |  Zhang, ZZ., et al. 2015. Am J Cancer Res. 5: 772-81. PMID: 25973314
10. Prognostic significance of TEM7 and nestin expression in women with advanced high grade serous ovarian cancer.  |  Czekierdowski, A., et al. 2018. Ginekol Pol. 89: 135-141. PMID: 29664548
11. Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.  |  Pietrzyk, Ł. and Wdowiak, P. 2019. Adv Med Sci. 64: 402-408. PMID: 31352222
12. Tumor Endothelial Marker TEM7 is a Prognostic Biomarker and Correlating with Immune Infiltrates in Gastric Cancer.  |  Geng, L., et al. 2021. Int J Gen Med. 14: 10155-10171. PMID: 34992436

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TEM7 Antibody (4H260) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TEM7 Antibody (4H260) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TEM7 Antibody (4H260) Specifications

Alternate Product Name: TEM7

Product Clone Name: 4H260

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 411-427

Epitope Target: TEM7

Epitope Species: human

Product Reactivity/Detection: TEM7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TEM7 Antibody (4H260): N/A