Telethonin Antibody (G-11): sc-25327

Telethonin Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Telethonin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Telethonin antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Telethonin plays a crucial role in muscle function, particularly in the assembly and maintenance of sarcomeres, which are the fundamental contractile units of striated muscle. By binding to titin, Telethonin helps stabilize the structure of myofibrils during muscle contraction and is essential for proper organization of the cytoskeleton during myofibrillogenesis. This interaction is vital for muscle integrity and function, as any disruption in Telethonin or titin can lead to muscle diseases. Telethonin is predominantly located in sarcomeres of cardiac and skeletal muscle, where Telethonin contributes to mechanical properties of muscle tissue and aids in transmission of force during contraction. Understanding Telethonin′s role in muscle physiology is important for developing therapeutic strategies for muscle-related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Telethonin Antibody (G-11) References:

1. Muscle assembly: a titanic achievement?  |  Gregorio, CC., et al. 1999. Curr Opin Cell Biol. 11: 18-25. PMID: 10047523
2. Titin: a molecular control freak.  |  Trinick, J. and Tskhovrebova, L. 1999. Trends Cell Biol. 9: 377-80. PMID: 10481174
3. Telethonin and other new proteins of the Z-disc of skeletal muscle.  |  Faulkner, G., et al. 2001. IUBMB Life. 51: 275-82. PMID: 11699871
4. Telethonin-deficiency initially presenting as a congenital muscular dystrophy.  |  Ferreiro, A., et al. 2011. Neuromuscul Disord. 21: 433-8. PMID: 21530252
5. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.  |  Knöll, R., et al. 2011. Circ Res. 109: 758-69. PMID: 21799151
6. Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes.  |  Candasamy, AJ., et al. 2014. J Biol Chem. 289: 1282-93. PMID: 24280220
7. Phosphorylation at Serines 157 and 161 Is Necessary for Preserving Cardiac Expression Level and Functions of Sarcomeric Z-Disc Protein Telethonin.  |  Lewis, HR., et al. 2021. Front Physiol. 12: 732020. PMID: 34566695
8. Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.  |  Li, C., et al. 2024. J Biol Chem. 300: 107254. PMID: 38569934
9. Titin as a scaffold and spring. Cytoskeleton.  |  Trinick, J. 1996. Curr Biol. 6: 258-60. PMID: 8805236
10. Telethonin, a novel sarcomeric protein of heart and skeletal muscle.  |  Valle, G., et al. 1997. FEBS Lett. 415: 163-8. PMID: 9350988
11. The clash in titin.  |  Means, AR. 1998. Nature. 395: 846-7. PMID: 9804415
12. Structural basis for activation of the titin kinase domain during myofibrillogenesis.  |  Mayans, O., et al. 1998. Nature. 395: 863-9. PMID: 9804419

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Telethonin Antibody (G-11) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-Telethonin Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Telethonin Antibody (G-11) Specifications

Alternate Product Name: Telethonin

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 58-167

Epitope Target: Telethonin

Epitope Species: human

Product Reactivity/Detection: telethonin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for Telethonin Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin