TECK Antibody (500-M48): sc-65377

TECK Antibody (500-M48) is a mouse monoclonal IgG1 antibody that detects chemokine C-C thymus expressed chemokine (TECK) in human samples through enzyme-linked immunosorbent assay (ELISA). TECK, also known as chemokine ligand 25 (CCL25), plays a crucial role in the immune system by guiding the migration of developing T cells within the thymus, which is essential for proper T cell development and function. CCL25 is predominantly expressed in thymic dendritic cells, thymic epithelial cells, and the small intestine, where CCL25 acts as a ligand for the CCR9 receptor. The interaction between CCL25 and CCR9 is vital for the navigation of thymocytes, ensuring that thymocytes reach appropriate locations for maturation. CCL25 has been shown to exert suppressive effects on immature subsets of myeloid progenitors that have been stimulated to proliferate by various growth factors, highlighting CCL25′s regulatory role in immune cell trafficking. Additionally, bone marrow pre-pro-B cells and cells capable of generating pro-B colonies in the presence of interleukin-7 and Flt-3 ligand are attracted to CCL25, a response that diminishes in later stages of B cell development, underscoring CCL25′s importance in early immune cell differentiation. Anti-TECK antibody (500-M48) is an invaluable tool for researchers studying T cell development and the intricate signaling pathways involved in immune responses.

The preferred TECK antibody is TECK Antibody (YY05): sc-80344.