TECK Antibody (YY05): sc-80344

TECK Antibody (YY05) is a rat monoclonal IgG2a antibody that detects TECK protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-TECK antibody (YY05) is available as the non-conjugated format. TECK protein, also known as chemokine ligand 25 (CCL25), plays a crucial role in the immune system by guiding the migration of developing T cells within the thymus, which is essential for proper immune function and development. TECK protein is predominantly expressed in thymic dendritic cells, thymic epithelial cells, and the small intestine, where CCL25 acts as a ligand for the CCR9 receptor. This interaction is vital for the navigation of thymocytes, particularly during their maturation process. TECK protein has been shown to exert suppressive effects on immature myeloid progenitor cells that have been stimulated by various growth factors, highlighting CCL25′s regulatory role in immune cell trafficking and development. Bone marrow pre-pro-B cells and pro-B colony-forming cells respond to TECK protein, indicating CCL25′s importance in early B cell development, a response that diminishes in later stages. TECK protein′s ability to influence cell migration and differentiation underscores CCL25′s significance in both T and B cell development, making TECK monoclonal antibody (YY05) a valuable tool for researchers studying immune cell dynamics and thymic function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TECK Antibody (YY05) References:

1. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors.  |  Broxmeyer, HE., et al. 1999. Ann N Y Acad Sci. 872: 142-62; discussion 163. PMID: 10372118
2. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling.  |  Norment, AM., et al. 2000. J Immunol. 164: 639-48. PMID: 10623805

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TECK Antibody (YY05) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TECK Antibody (YY05) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TECK Antibody (YY05) Specifications

Alternate Product Name: TECK

Product Clone Name: YY05

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: TECK

Epitope Species: mouse

Product Reactivity/Detection: TECK

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TECK Antibody (YY05): L: Azide-Free