Tctex5 Antibody (D-9): sc-376034

Tctex5 Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tctex5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Tctex5 antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tctex5, also known as PPP1R11 (protein phosphatase 1, regulatory (inhibitor) subunit 11), HCGV, or TCTE5, is a 126 amino acid protein that plays a crucial role as an inhibitor of protein phosphatase 1 (PP1), which is essential for regulating various cellular processes, including cell division, metabolism, and signal transduction. The inhibition of PP1 by Tctex5 helps maintain the balance of phosphorylation states within cells, thereby influencing numerous signaling pathways that affect cell growth and differentiation. Tctex5 exhibits 87% sequence similarity with its mouse counterpart, indicating evolutionary conservation across species such as rat, cow, dog, and rabbit. The gene encoding Tctex5 is located on human chromosome 6, a region associated with several genetic disorders, including early onset intestinal cancer and various neurodegenerative diseases. Understanding Tctex5′s function and regulatory role in cellular signaling pathways is vital for elucidating potential implications in cancer susceptibility and other diseases linked to chromosome 6.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Tctex5 Antibody (D-9) References:

1. The DNA sequence and analysis of human chromosome 6.  |  Mungall, AJ., et al. 2003. Nature. 425: 805-11. PMID: 14574404
2. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.  |  Lesage, B., et al. 2007. Biochemistry. 46: 8909-19. PMID: 17630778
3. Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response.  |  Huang, HS. and Lee, EY. 2008. J Biol Chem. 283: 18135-46. PMID: 18450750
4. Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells.  |  Li, H., et al. 2017. Gastroenterology. 153: 505-520. PMID: 28435028
5. DYNLT1 gene expression is downregulated in whole blood of patients at different Huntington's disease stages.  |  Rosseto, SM., et al. 2021. Neurol Sci. 42: 1963-1967. PMID: 32995988
6. Vitiligo progression in a patient undergoing romosozumab treatment for osteoporosis.  |  Trepanowski, N., et al. 2023. JAAD Case Rep. 42: 26-30. PMID: 37965188
7. Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes.  |  Amadou, C., et al. 1995. Genomics. 26: 9-20. PMID: 7782091
8. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region.  |  Giffon, T., et al. 1996. Immunogenetics. 44: 331-9. PMID: 8781118
9. Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence.  |  Lepourcelet, M., et al. 1996. Genomics. 37: 316-26. PMID: 8938444
10. Genomic evolution of the distal Mhc class I region on mouse Chr 17.  |  Yoshino, M., et al. 1997. Hereditas. 127: 141-8. PMID: 9420479
11. BAC/YAC contigs from the H2-M region of mouse Chr 17 define gene order as Znf173-Tctex5-mog-D17Tu42-M3-M2.  |  Yoshino, M., et al. 1998. Immunogenetics. 47: 371-80. PMID: 9510555
12. Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1.  |  Zhang, J., et al. 1998. Biochemistry. 37: 16728-34. PMID: 9843442

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tctex5 Antibody (D-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Tctex5 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tctex5 Antibody (D-9) Specifications

Alternate Product Name: Tctex5

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-126

Epitope Target: Tctex5

Epitope Species: human

Product Reactivity/Detection: Tctex5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Tctex5 Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin