TCR V β 8.5 Antibody (B73): sc-59388

TCR V β 8.5 Antibody (B73) is a mouse monoclonal IgG1 antibody that detects the T cell receptor V β 8.5 protein of mouse and rat species by flow cytometry (FCM). TCR V β 8.5 plays a crucial role in the immune response by enabling T cells to recognize and bind to specific foreign antigens, which is essential for the activation and proliferation of T cells during an immune response. This protein is primarily located on the surface of T cells, where TCR V β 8.5 forms part of the T cell receptor complex, allowing for the precise recognition of antigens presented by major histocompatibility complex (MHC) molecules. The ability of TCR V β 8.5 to interact with a diverse array of antigens is vital for the adaptive immune system, as TCR V β 8.5 ensures that T cells can respond effectively to a wide range of pathogens. Furthermore, TCR V β 8.5 undergoes various post-translational modifications, such as glycosylation, which can influence stability, localization, and interaction with other proteins, thereby impacting T cell activation and function. Anti-TCR V β 8.5 antibody (B73) is an invaluable tool for researchers studying T cell biology and the mechanisms of immune responses, providing insights into T cell development, activation, and the overall functioning of the immune system.

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TCR V β 8.5 Antibody (B73) References:

1. TCR v(beta) repertoire restriction and lack of CDR3 conservation implicate TCR-superantigen interactions in promoting the clonal evolution of murine thymic lymphomas.  |  Gomez, G., et al. 2000. Int Immunol. 12: 263-70. PMID: 10700461
2. Cutting edge: influence of the TCR V beta domain on the avidity of CD1d:alpha-galactosylceramide binding by invariant V alpha 14 NKT cells.  |  Schümann, J., et al. 2003. J Immunol. 170: 5815-9. PMID: 12794105
3. T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats.  |  Hashim, G., et al. 1991. J Immunol. 146: 515-20. PMID: 1702803
4. The inflammatory lesion of T cell line transferred experimental autoimmune encephalomyelitis of the Lewis rat: distinct nature of parenchymal and perivascular infiltrates.  |  Lannes-Vieira, J., et al. 1994. Acta Neuropathol. 87: 435-42. PMID: 7520206
5. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease.  |  Gold, R., et al. 1995. Proc Natl Acad Sci U S A. 92: 5850-4. PMID: 7597040
6. Preferential distribution of V beta 8.2-positive T cells in the central nervous system of rats with myelin basic protein-induced autoimmune encephalomyelitis.  |  Tsuchida, M., et al. 1993. Eur J Immunol. 23: 2399-406. PMID: 7691605
7. Characterization of the autoreactive T cell repertoire in cyclosporin-induced syngeneic graft-versus-host disease. A highly conserved repertoire mediates autoaggression.  |  Fischer, AC., et al. 1995. J Immunol. 154: 3713-25. PMID: 7706714
8. Analysis of heart-infiltrating T-cell clonotypes in experimental autoimmune myocarditis in rats.  |  Hanawa, H., et al. 1996. Circ Res. 78: 118-25. PMID: 8603494
9. Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine.  |  Helgeland, L., et al. 1996. Immunology. 89: 494-501. PMID: 9014812
10. Cloning, functional activities and in vivo tissue distribution of rat NKR-P1+ TCR alpha beta + cells.  |  Knudsen, E., et al. 1997. Int Immunol. 9: 1043-51. PMID: 9237113

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.