TCR V β 13.2 Antibody (H132): sc-81761

TCR V β 13.2 Antibody (H132) is a mouse monoclonal IgG1 kappa light chain antibody that detects TCR V beta 13.2 protein of human origin by western blotting (WB) and flow cytometry (FCM). TCR V β 13.2 (H132) antibody is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling pathways that lead to T cell activation. TCR is a heterodimer, typically composed of either alpha and beta or gamma and delta chains, with approximately 95% of circulating T cells expressing the alpha/beta heterodimer. This diversity in TCR specificity is essential for the immune system to effectively recognize a wide array of antigens, achieved through somatic recombination of variable (V), diversity (D), and joining (J) gene segments during T cell development. TCR beta chain undergoes a complex assembly process, where a D segment first joins with a J segment, followed by addition of a V segment, and finally a constant (C) segment. Genetic mutations in TCR beta locus have been linked to development of T cell lymphomas, highlighting TCR′s importance in both immune function and disease pathology.

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TCR V β 13.2 Antibody (H132) References:

1. Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.  |  Behlke, MA., et al. 1987. J Exp Med. 165: 257-62. PMID: 2432150
2. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.  |  Staerz, UD., et al. 1985. J Immunol. 134: 3994-4000. PMID: 2580901
3. Expansion of Tumor-reactive T Cells From Patients With Pancreatic Cancer.  |  Meng, Q., et al. 2016. J Immunother. 39: 81-9. PMID: 26849077
4. Methods for the selection and growth of antigen-specific cytolytic T lines and clones bearing a defined T cell receptor beta chain marker.  |  Ito, M., et al. 1987. J Immunol Methods. 103: 229-37. PMID: 2959725
5. A mouse monoclonal antibody specific for the V beta 5.3 chain of the human TcR recognizes a subgroup of the mouse TcR V beta 8.2 chains.  |  Bleux, C., et al. 1995. J Leukoc Biol. 57: 491. PMID: 7884322
6. Dominant V beta 8 gene usage in response to TNP: failure to use other V beta chains following removal of V beta 8+ T cells by monoclonal antibody in vivo.  |  Dieli, F., et al. 1994. Immunology. 82: 99-105. PMID: 8045598
7. T cell vaccination against autoimmune diabetes in nonobese diabetic mice.  |  Formby, B. and Shao, T. 1993. Ann Clin Lab Sci. 23: 137-47. PMID: 8096128
8. T cell receptor V beta gene bias in rheumatoid arthritis.  |  Jenkins, RN., et al. 1993. J Clin Invest. 92: 2688-701. PMID: 8254025
9. Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.  |  Mokyr, MB., et al. 1993. J Immunol. 151: 4838-46. PMID: 8409442
10. Limited usage of T cell receptor V beta genes by allopeptide-specific T cells.  |  Liu, Z., et al. 1993. J Immunol. 150: 3180-6. PMID: 8468463
11. Overexpression of select T cell receptor V beta gene families within CD4+ and CD8+ T cell subsets of myasthenia gravis patients: a role for superantigen(s)?  |  Gigliotti, D., et al. 1996. Mol Med. 2: 452-9. PMID: 8827715
12. Subtype-specific interactions of type C staphylococcal enterotoxins with the T-cell receptor.  |  Deringer, JR., et al. 1996. Mol Microbiol. 22: 523-34. PMID: 8939435

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.