TCR V β 10 Antibody (G101): sc-59381

TCR V β 10 Antibody (G101) is a mouse monoclonal IgG2a kappa light chain antibody that detects TCR V beta 10 protein of mouse and rat origin by flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). Anti-TCR V beta 10 antibody (G101) is available as the non-conjugated format. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling pathways that lead to T cell activation. This process is vital for the adaptive immune system, as TCR enables T cells to respond effectively to pathogens. TCR is a heterodimer composed of either alpha and beta or gamma and delta chains, with the majority of circulating T cells (approximately 95%) expressing the alpha/beta heterodimer. TCR repertoire diversity, essential for recognizing a wide array of antigens, is achieved through somatic recombination of variable (V), diversity (D), and joining (J) gene segments during T cell development. TCR beta and gamma chain genes are located in distinct loci, while alpha and delta chain genes are found within a single locus. Genetic mutations in TCR beta locus have been linked to T cell lymphoma development, highlighting TCR integrity′s importance in maintaining immune health.

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TCR V β 10 Antibody (G101) References:

1. Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.  |  Behlke, MA., et al. 1987. J Exp Med. 165: 257-62. PMID: 2432150
2. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.  |  Staerz, UD., et al. 1985. J Immunol. 134: 3994-4000. PMID: 2580901
3. Methods for the selection and growth of antigen-specific cytolytic T lines and clones bearing a defined T cell receptor beta chain marker.  |  Ito, M., et al. 1987. J Immunol Methods. 103: 229-37. PMID: 2959725
4. A mouse monoclonal antibody specific for the V beta 5.3 chain of the human TcR recognizes a subgroup of the mouse TcR V beta 8.2 chains.  |  Bleux, C., et al. 1995. J Leukoc Biol. 57: 491. PMID: 7884322
5. Dominant V beta 8 gene usage in response to TNP: failure to use other V beta chains following removal of V beta 8+ T cells by monoclonal antibody in vivo.  |  Dieli, F., et al. 1994. Immunology. 82: 99-105. PMID: 8045598
6. T cell vaccination against autoimmune diabetes in nonobese diabetic mice.  |  Formby, B. and Shao, T. 1993. Ann Clin Lab Sci. 23: 137-47. PMID: 8096128
7. Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.  |  Mokyr, MB., et al. 1993. J Immunol. 151: 4838-46. PMID: 8409442

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.