TCP-1 γ Antibody (F-3): sc-271336

TCP-1 γ Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects TCP-1 gamma in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 γ (F-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TCP-1, also known as t complex polypeptide 1, is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. Located in the eukaryotic cytosol, the CCT complex comprises eight distinct subunits, each encoded by different genes, and is vital for maintaining cellular function and integrity. TCP-1′s role in protein folding is particularly important, as misfolded proteins can lead to cellular dysfunction and various diseases. TCP-1 was initially identified in mice, where TCP-1 was linked to tail-less and embryonic lethal phenotypes, and homologous sequences have been found in several other species, underscoring evolutionary significance. The yeast version of TCP-1 functions as a molecular chaperone for actin and tubulin, highlighting TCP-1′s conserved role across different organisms.

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TCP-1 γ Antibody (F-3) References:

1. Upregulation of cytosolic chaperonin CCT subunits during recovery from chemical stress that causes accumulation of unfolded proteins.  |  Yokota, SI., et al. 2000. Eur J Biochem. 267: 1658-64. PMID: 10712596
2. Cloning of the chaperonin t-complex polypeptide 1 gene from Schistosoma mansoni and studies of its expression levels under heat shock and oxidative stress.  |  Campos, EG. and Hamdan, FF. 2000. Parasitol Res. 86: 253-8. PMID: 10726997
3. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin.  |  Hynes, GM. and Willison, KR. 2000. J Biol Chem. 275: 18985-94. PMID: 10748209
4. Defining the eukaryotic cytosolic chaperonin-binding sites in human tubulins.  |  Ritco-Vonsovici, M. and Willison, KR. 2000. J Mol Biol. 304: 81-98. PMID: 11071812
5. Suppression of CCT3 Inhibits Tumor Progression by Impairing ATP Production and Cytoplasmic Translation in Lung Adenocarcinoma.  |  Chen, S., et al. 2022. Int J Mol Sci. 23: PMID: 35409343
6. Current understanding on the role of CCT3 in cancer research.  |  Liu, W., et al. 2022. Front Oncol. 12: 961733. PMID: 36185198
7. Insights into the roles and driving forces of CCT3 in human tumors.  |  Ma, J., et al. 2022. Front Pharmacol. 13: 1005855. PMID: 36313331
8. CCT3 as a Diagnostic and Prognostic Biomarker in Cervical Cancer.  |  Li, M., et al. 2023. Crit Rev Eukaryot Gene Expr. 33: 17-28. PMID: 37522542
9. Circular RNA CCT3 is a unique molecular marker in bladder cancer.  |  Luo, L., et al. 2023. BMC Cancer. 23: 977. PMID: 37833621
10. CCT3/ACTN4/TFRC axis protects hepatocellular carcinoma cells from ferroptosis by inhibiting iron endocytosis.  |  Zhu, H., et al. 2024. J Exp Clin Cancer Res. 43: 245. PMID: 39210442
11. Cucumber T-complex protein. Molecular cloning, bacterial expression and characterization within a 22-S cytosolic complex in cotyledons and hypocotyls.  |  Ahnert, V., et al. 1996. Eur J Biochem. 235: 114-9. PMID: 8631317
12. A Dictyostelium discoideum homologue to Tcp-1 is essential for growth and development.  |  Iijima, M., et al. 1998. Gene. 213: 101-6. PMID: 9630545

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TCP-1 γ Antibody (F-3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TCP-1 γ Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TCP-1 γ Antibody (F-3) Specifications

Alternate Product Name: TCP-1 γ

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 101-400

Epitope Target: TCP-1 γ

Epitope Species: human

Product Reactivity/Detection: TCP-1 γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TCP-1 γ Antibody (F-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin