TCP-1 β Antibody (A-5): sc-373769

TCP-1 β Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects TCP-1 β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 β is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and TCP-1 β plays a significant role in ensuring that these proteins achieve their functional conformations. TCP-1 β functions extend beyond protein folding to cellular processes such as cytoskeletal organization and cellular signaling, which are vital for maintaining cellular integrity and function. Abnormalities in TCP-1 β expression or function can lead to various diseases, including neurodegenerative disorders, highlighting TCP-1 β significance in both health and disease. Anti-TCP-1 β antibody (A-5) serves as an invaluable tool for researchers studying protein folding dynamics and chaperonin function in various biological contexts.

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TCP-1 β Antibody (A-5) References:

1. Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.  |  Zou, Q., et al. 2013. World J Surg Oncol. 11: 143. PMID: 23782473
2. Chaperonin-containing t-complex protein-1 subunit β as a possible biomarker for the phase of glomerular hyperfiltration of diabetic nephropathy.  |  Wu, CZ., et al. 2015. Dis Markers. 2015: 548101. PMID: 25944975
3. Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis.  |  Wang, Q., et al. 2019. Vet Microbiol. 235: 151-163. PMID: 31282373
4. Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer.  |  Park, SH., et al. 2020. Oncogene. 39: 136-150. PMID: 31462707
5. Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer.  |  Liu, Q., et al. 2021. Front Oncol. 11: 614497. PMID: 33869000
6. CCT2, a newly identified aggrephagy receptor in mammals, specifically mediates the autophagic clearance of solid protein aggregates.  |  Zhang, Z. and Klionsky, DJ. 2022. Autophagy. 18: 1483-1485. PMID: 35699934
7. Tat-CCT2 Protects the Neurons from Ischemic Damage by Reducing Oxidative Stress and Activating Autophagic Removal of Damaged Protein in the Gerbil Hippocampus.  |  Kwon, HJ., et al. 2023. Neurochem Res. 48: 3585-3596. PMID: 37561257
8. Circ-CCT2 Activates Wnt/β-catenin Signaling to Facilitate Hepatoblastoma Development by Stabilizing PTBP1 mRNA.  |  Zhu, Q., et al. 2024. Cell Mol Gastroenterol Hepatol. 17: 175-197. PMID: 37866478
9. Lassa virus Z protein hijacks the autophagy machinery for efficient transportation by interrupting CCT2-mediated cytoskeleton network formation.  |  Yuan, Y., et al. 2024. Autophagy. 20: 2511-2528. PMID: 39007910
10. CCT2 Regulates ZEB1-Induced EMT Gene Transcription to Promote the Metastasis and Tumorigenesis of Papillary Thyroid Carcinoma.  |  Liu, W., et al. 2024. Discov Med. 36: 1819-1830. PMID: 39327245

The preferred TCP-1 β antibody is TCP-1 β Antibody (D-8): sc-374152.