TCL-1B Antibody (E-1): sc-515117

TCL-1B Antibody (E-1) is a mouse monoclonal IgG3 antibody that detects T cell leukemia/lymphoma protein 1B (TCL-1B) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCL-1B, also known as TML1, TCL/MTCP1-like 1, syncytiotrophoblast-specific protein, and SYN-1, plays a critical role in T cell prolymphocytic leukemia (T-PLL) and is located on human chromosome 14q32.1, a region frequently implicated in chromosomal translocations and inversions associated with T cell leukemias and lymphomas. TCL-1B is activated by chromosomal rearrangements involving the TCL1 locus, highlighting TCL-1B′s significance in oncogenic processes. TCL-1B is found in both the nucleus and cytoplasm of normal bone marrow and peripheral lymphocytes, which is essential for TCL-1B′s function in cellular signaling and regulation. The crystal structure of TCL-1B suggests that TCL-1B may facilitate the transport of small molecules, including retinoids, nucleotides, and fatty acids, thereby influencing various metabolic pathways and cellular functions. With diverse applications and a critical role in T cell biology, anti-TCL-1B antibody (E-1) serves as an invaluable tool for researchers studying T cell malignancies and related signaling pathways.

The preferred TCL-1B antibody is TCL-1B Antibody (H-3): sc-365169.