TCL-1B Antibody (H-3): sc-365169
- TCL-1B Antibody (H-3) is a mouse monoclonal IgG1 κ TCL-1B antibody provided at 200 µg/ml
- raised against amino acids 1-90 mapping at the N-terminus of TCL-1B of human origin
- TCL-1B Antibody (H-3) is recommended for detection of TCL-1B of human origin by WB, IP, IF and ELISA
- Anti-TCL-1B Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TCL-1B Antibody (H-3) for WB applications. These reagents are now offered in bundles with TCL-1B Antibody (H-3) (see ordering information below).
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TCL-1B Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects TCL-1B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCL-1B (H-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The T cell leukemia/lymphoma protein 1B (TCL-1B), also known as TML1, TCL/MTCP1-like 1, syncytiotrophoblast-specific protein, and SYN-1, plays a critical role in T cell prolymphocytic leukemia (T-PLL) and is located on human chromosome 14q32.1, a region frequently involved in chromosomal translocations and inversions associated with T cell leukemias and lymphomas. TCL-1B is activated by chromosomal rearrangements involving the TCL1 locus, which can lead to aberrant signaling pathways that promote cell survival and proliferation. TCL-1B′s structure, characterized by a unique fold that facilitates interaction with various signaling molecules, is essential for regulating T cell development and activation. In mice, TCL-1B is represented by five homologues, TCL-1B1 to TCL-1B5, which underscores evolutionary significance. TCL-1B expression in both nucleus and cytoplasm of normal bone marrow and peripheral lymphocytes highlights versatile roles in cellular processes, making TCL-1B a valuable target for research and therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCL-1B Antibody (H-3) References:
- Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. | Pekarsky, Y., et al. 1999. Proc Natl Acad Sci U S A. 96: 2949-51. PMID: 10077617
- Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. | Sugimoto, J., et al. 1999. Cancer Res. 59: 2313-7. PMID: 10344735
- Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. | Hallas, C., et al. 1999. Proc Natl Acad Sci U S A. 96: 14418-23. PMID: 10588720
- Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. | Pekarsky, Y., et al. 2000. Proc Natl Acad Sci U S A. 97: 3028-33. PMID: 10716693
- Characterization and localization of the TCL-1 oncogene product. | Fu, TB., et al. 1994. Cancer Res. 54: 6297-301. PMID: 7987816
- Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. | Fu, ZQ., et al. 1998. Proc Natl Acad Sci U S A. 95: 3413-8. PMID: 9520380
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCL-1B Antibody (H-3) | sc-365169 | 200 µg/ml | $322.00 | |||
TCL-1B Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-527337 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCL-1B Antibody (H-3): m-IgG1 BP-HRP Bundle | sc-532710 | 200 µg Ab; 20 µg BP | $361.00 | |||
TCL-1B Antibody (H-3) AC | sc-365169 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TCL-1B Antibody (H-3) HRP | sc-365169 HRP | 200 µg/ml | $322.00 | |||
TCL-1B Antibody (H-3) FITC | sc-365169 FITC | 200 µg/ml | $336.00 | |||
TCL-1B Antibody (H-3) PE | sc-365169 PE | 200 µg/ml | $349.00 | |||
TCL-1B Antibody (H-3) Alexa Fluor® 488 | sc-365169 AF488 | 200 µg/ml | $364.00 | |||
TCL-1B Antibody (H-3) Alexa Fluor® 546 | sc-365169 AF546 | 200 µg/ml | $364.00 | |||
TCL-1B Antibody (H-3) Alexa Fluor® 594 | sc-365169 AF594 | 200 µg/ml | $364.00 | |||
TCL-1B Antibody (H-3) Alexa Fluor® 647 | sc-365169 AF647 | 200 µg/ml | $364.00 | |||
TCL-1B Antibody (H-3) Alexa Fluor® 680 | sc-365169 AF680 | 200 µg/ml | $364.00 | |||
TCL-1B Antibody (H-3) Alexa Fluor® 790 | sc-365169 AF790 | 200 µg/ml | $364.00 |