TBK1 Antibody (6D603): sc-73115
- TBK1 Antibody (6D603) is a mouse monoclonal IgG1, cited in 5 publications, provided at 50 µg/500 µl
- raised against a synthetic peptide corresponding to amino acids 563-577 of TBK1 of human origin
- recommended for detection of TBK1 of mouse, rat, human, bovine and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TBK1 Antibody (6D603). This work is in progress.
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TBK1 Antibody (6D603) is a mouse monoclonal IgG1 antibody that detects TBK1 in mouse, rat, human, bovine, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. TBK1, or TANK binding kinase 1, plays a crucial role in the regulation of the NFkB signaling pathway, which is essential for immune response and inflammation. TBK1 is primarily located in the cytoplasm, where TBK1 interacts with various signaling molecules to modulate the activation of NFkB. TBK1′s cytoplasmic localization enables rapid response to cellular stress and inflammatory signals, facilitating the phosphorylation of IkB proteins and promoting the degradation of IkBα, thereby allowing NFkB to translocate to the nucleus and initiate transcription of target genes. TBK1′s activity extends to involvement in various diseases, including cancer and autoimmune disorders, making TBK1 a significant target for therapeutic intervention. Anti-TBK1 antibody (6D603) serves as an invaluable tool for researchers studying the intricate mechanisms of NFkB activation and broader implications in cellular signaling pathways.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBK1 Antibody (6D603) References:
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. | Barbie, DA., et al. 2009. Nature. 462: 108-12. PMID: 19847166
- TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation. | Lafont, E., et al. 2018. Nat Cell Biol. 20: 1389-1399. PMID: 30420664
- RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. | Heo, JM., et al. 2018. Sci Adv. 4: eaav0443. PMID: 30627666
- Structural basis of STING binding with and phosphorylation by TBK1. | Zhang, C., et al. 2019. Nature. 567: 394-398. PMID: 30842653
- Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. | Taft, J., et al. 2021. Cell. 184: 4447-4463.e20. PMID: 34363755
- The role of TBK1 in cancer pathogenesis and anticancer immunity. | Runde, AP., et al. 2022. J Exp Clin Cancer Res. 41: 135. PMID: 35395857
- AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity. | Zhang, Q., et al. 2022. Mol Cell. 82: 4519-4536.e7. PMID: 36384137
- Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS. | Watanabe, S., et al. 2023. Proc Natl Acad Sci U S A. 120: e2315347120. PMID: 37967220
- PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling. | Lin, Y., et al. 2023. Nat Commun. 14: 7567. PMID: 37989995
- NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. | Paul, S., et al. 2024. J Cell Biol. 223: PMID: 38059900
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBK1 Antibody (6D603) | sc-73115 | 50 µg/500 µl | $322.00 |