TBK1 Antibody (108A429): sc-52957

TBK1 Antibody (108A429) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBK1 from mouse, rat, human, bovine, and canine origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TBK1 antibody (108A429) is available in non-conjugated form. TBK1, also known as TANK binding kinase 1, plays a crucial role in regulating the NFκB signaling pathway, vital for immune response and inflammation. TBK1 is primarily located in the cytoplasm, where TBK1 interacts with various signaling molecules to modulate NFκB activity. TBK1′s cytoplasmic localization enables rapid response to cellular stress and infection, facilitating IκB protein phosphorylation, which leads to IκB degradation and subsequent NFκB release and activation. This process is essential for transcribing genes involved in immune responses, making TBK1 a key player in defense mechanisms. TBK1 also interacts with TRAF2 and TANK, further highlighting TBK1′s role in NFκB activation pathway. The functional IKK complex, including TBK1, IKKα, and IKKβ, underscores these kinases′ collaborative nature in regulating critical cellular processes.

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TBK1 Antibody (108A429) References:

1. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.  |  Pomerantz, JL. and Baltimore, D. 1999. EMBO J. 18: 6694-704. PMID: 10581243
2. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.  |  Xu, D., et al. 2018. Cell. 174: 1477-1491.e19. PMID: 30146158
3. TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.  |  Balka, KR., et al. 2020. Cell Rep. 31: 107492. PMID: 32268090
4. TBK1-METTL3 axis facilitates antiviral immunity.  |  Chen, J., et al. 2022. Cell Rep. 38: 110373. PMID: 35172162
5. Targeting TBK1 to overcome resistance to cancer immunotherapy.  |  Sun, Y., et al. 2023. Nature. 615: 158-167. PMID: 36634707
6. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.  |  Verma, IM., et al. 1995. Genes Dev. 9: 2723-35. PMID: 7590248
7. NF-kappa B: a lesson in family values.  |  Thanos, D. and Maniatis, T. 1995. Cell. 80: 529-32. PMID: 7867060
8. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.  |  Connelly, MA. and Marcu, KB. 1995. Cell Mol Biol Res. 41: 537-49. PMID: 8777433
9. Identification and characterization of an IkappaB kinase.  |  Régnier, CH., et al. 1997. Cell. 90: 373-83. PMID: 9244310
10. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.  |  DiDonato, JA., et al. 1997. Nature. 388: 548-54. PMID: 9252186
11. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.  |  Zandi, E., et al. 1997. Cell. 91: 243-52. PMID: 9346241
12. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.  |  Yamaoka, S., et al. 1998. Cell. 93: 1231-40. PMID: 9657155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBK1 Antibody (108A429) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-TBK1 Antibody (108A429) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBK1 Antibody (108A429) Specifications

Alternate Product Name: TANK binding kinase 1

Product Clone Name: 108A429

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 563-577

Epitope Target: TBK1

Epitope Species: human

Product Reactivity/Detection: TBK1

Species Reactivity/Detection: mouse, rat, human, bovine, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for TBK1 Antibody (108A429): N/A