TBCK Antibody (WW-8): sc-81865

TBCK Antibody (WW-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects TBCK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TBCK antibody (WW-8) is available as the non-conjugated form. TBCK protein, also known as TBC domain-containing protein kinase-like protein, TBCKL, or MGC16169 in humans, and A630047E20Rik in mice, consists of 893 amino acids and belongs to the protein kinase superfamily. TBCK (WW-8) antibody recognizes a crucial protein involved in cellular signaling pathways, particularly in regulating small GTPases, which are essential for various cellular processes including growth, differentiation, and vesicle trafficking. A Rab-GAP TBC domain within TBCK facilitates Rab proteins inactivation, influencing intracellular transport and communication. TBCK contains a protein kinase domain and a rhodanese domain, potentially involved in sulfur group transfer, highlighting its multifaceted role in cellular metabolism. Four isoforms of TBCK arise from alternative splicing, allowing for functional diversity in activity. TBCK gene is located on human chromosome 4q24, a region containing nearly 900 genes and associated with various genetic disorders, including Huntington′s disease and achondroplasia. TBCK monoclonal antibody (WW-8) effectively detects this important protein, making this reagent valuable for studying its role in health and disease.

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TBCK Antibody (WW-8) References:

1. Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements.  |  Dobson, CM., et al. 2002. Proc Natl Acad Sci U S A. 99: 15554-9. PMID: 12438653
2. Selective neuronal degeneration in Huntington's disease.  |  Cowan, CM. and Raymond, LA. 2006. Curr Top Dev Biol. 75: 25-71. PMID: 16984809
3. Syndromic craniosynostosis: from history to hydrogen bonds.  |  Cunningham, ML., et al. 2007. Orthod Craniofac Res. 10: 67-81. PMID: 17552943
4. Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.  |  Ruiz-Perez, VL., et al. 2007. Development. 134: 2903-12. PMID: 17660199
5. Growth hormone analysis and treatment in Ellis-van Creveld syndrome.  |  Versteegh, FG., et al. 2007. Am J Med Genet A. 143A: 2113-21. PMID: 17702014
6. Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle.  |  Chandler, RJ., et al. 2007. BMC Med Genet. 8: 64. PMID: 17937813
7. Muenke syndrome (FGFR3-related craniosynostosis): expansion of the phenotype and review of the literature.  |  Doherty, ES., et al. 2007. Am J Med Genet A. 143A: 3204-15. PMID: 18000976
8. Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.  |  Stack, EC., et al. 2007. J Neurosci. 27: 12908-15. PMID: 18032664
9. Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias.  |  de Frutos, CA., et al. 2007. Dev Cell. 13: 872-83. PMID: 18061568

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBCK Antibody (WW-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TBCK Antibody (WW-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBCK Antibody (WW-8) Specifications

Alternate Product Name: TBCK

Product Clone Name: WW-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 601-701

Epitope Target: TBCK

Epitope Species: human

Product Reactivity/Detection: TBCK

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TBCK Antibody (WW-8): N/A