TBCK Activators
TBCK, situated in the nexus of mTORC1 signaling, has an influence that is underpinned by an intricate interplay of cellular mechanisms. Chemicals like Forskolin, which elevate cAMP levels, delineate how cyclic nucleotides might pivot the balance of mTORC1 signaling, with a subsequent influence on TBCK. Rapamycin, LY294002, and U0126 offer a deeper dive into the broader signaling domains, elucidating how the inhibition of mTOR and PI3K or modulation of MAPK pathways can cascade to affect TBCK's activity.
Metabolic modulators, such as Insulin and Amino acids, spotlight the dynamic nature of metabolic pathways and their sway over TBCK. The involvement of Metformin and AICAR in AMPK and mTOR signaling exemplifies how the energy state of a cell can modulate TBCK indirectly. Further, IGF-1, with its propensity to stimulate the PI3K-Akt-mTOR axis, underscores the multifaceted regulatory elements that can influence TBCK. Chemicals like W-7 hydrochloride add depth to this understanding, proposing that calcium-sensitive processes can intertwine with the TBCK landscape. Lastly, Chloroquine and Dactolisib bring forth the autophagy dimension and further expand on the PI3K/mTOR modulation, respectively, solidifying the intricate chemical tapestry that can regulate TBCK activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which can regulate mTORC1 signaling and subsequently TBCK. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that indirectly modulates mTORC1 signaling, which may affect TBCK activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor can influence mTOR signaling and TBCK indirectly. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Can activate the PI3K-Akt-mTOR pathway and therefore may indirectly affect TBCK. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Affects AMPK and mTOR signaling, potentially modulating TBCK activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator which can influence mTOR signaling and thereby TBCK. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calcium/calmodulin antagonist that may influence calcium-sensitive cellular processes linked to TBCK. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Affects autophagy and can influence mTOR signaling, potentially modulating TBCK. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
Dual PI3K/mTOR inhibitor that can indirectly modulate TBCK via mTOR signaling. | ||||||