TBCCD1 Antibody (D-2): sc-515156

TBCCD1 Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBCCD1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBCCD1 Antibody (D-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBCCD1, which consists of 557 amino acids, features a C-CAP/cofactor C-like domain that plays a crucial role in cellular processes such as protein folding and assembly. This domain is essential for TBCCD1′s function in the cytosol, where TBCCD1 interacts with other proteins to facilitate proper assembly of multiprotein complexes, thereby influencing cellular signaling pathways and maintaining cellular homeostasis. TBCCD1 is located on Chromosome 3, a region associated with various genetic diseases and cancer-related loci, highlighting TBCCD1′s importance in both normal physiology and disease states. Understanding TBCCD1′s interactions and functions can provide insights into its role in tumor suppression and potential implications for therapeutic strategies targeting related pathways.

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TBCCD1 Antibody (D-2) References:

1. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.  |  Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
2. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
3. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
4. Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2.  |  Yue, Y., et al. 2005. Cytogenet Genome Res. 108: 98-105. PMID: 15545721
5. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
6. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'.  |  Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
7. The DNA sequence, annotation and analysis of human chromosome 3.  |  Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
8. Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3.  |  Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193
9. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning.  |  Gonçalves, J., et al. 2010. EMBO Rep. 11: 194-200. PMID: 20168327
10. The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation.  |  André, J., et al. 2013. J Cell Sci. 126: 5350-6. PMID: 24101722
11. DISTAG/TBCCd1 Is Required for Basal Cell Fate Determination in Ectocarpus.  |  Godfroy, O., et al. 2017. Plant Cell. 29: 3102-3122. PMID: 29208703
12. The baseless mutant links protein phosphatase 2A with basal cell identity in the brown alga Ectocarpus.  |  Godfroy, O., et al. 2023. Development. 150: PMID: 36786333

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBCCD1 Antibody (D-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TBCCD1 Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBCCD1 Antibody (D-2) Specifications

Alternate Product Name: TBCCD1

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 401-447

Epitope Target: TBCCD1

Epitope Species: human

Product Reactivity/Detection: TBCCD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TBCCD1 Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin