TBCCD1 Inhibitors
TBCCD1 inhibitors are a diverse set of chemical compounds that decrease the functional activity of TBCCD1 by influencing the microtubule dynamics TBCCD1 is known to stabilize. For instance, compounds like Palbociclib, Vincristine, and Nocodazole, through their distinct mechanisms, indirectly limit the role TBCCD1 plays in microtubule dynamics. PD 0332991 induces a G1 phase cell cycle arrest, thereby reducing the cellular processes that necessitate TBCCD1's function in microtubule dynamics. Vincristine and Nocodazole, both disruptors of microtubuleassembly, diminish the need for TBCCD1's stabilizing activity by either inhibiting the polymerization of tubulin or causing the depolymerization of microtubules, respectively. These inhibitors, by interfering with the microtubule structures, reduce the cellular reliance on TBCCD1's role in maintaining microtubule integrity during cell division and other crucial cellular processes.
Additionally, other inhibitors such as Taxol and Eribulin exert their effects by stabilizing microtubules, which paradoxically diminishes the requirement for TBCCD1's stabilizing influence. Similarly, Colchicine, Podophyllotoxin, Griseofulvin, and Thiabendazole all target tubulin and microtubule assembly, thereby indirectly reducing the functional activity of TBCCD1 by circumventing the typical microtubule dynamics that TBCCD1 is designed to support. Vinflunine, Peloruside A, and Laulimalide, while each having a unique molecular target and mechanism, all share the common outcome of diminishing TBCCD1 activity by stabilizing microtubules and thereby reducing the requirement for TBCCD1's role in microtubule stabilization. Together, these compounds represent a comprehensive approach to diminishing TBCCD1 activity by targeting the microtubule dynamics that TBCCD1 is intrinsically associated with, not by inhibiting the protein directly but by altering the microtubule landscape in which TBCCD1 operates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
A CDK4/6 inhibitor that leads to cell cycle arrest at G1 phase. TBCCD1 is involved in microtubule dynamics crucial for cell division. By arresting the cell cycle, Palbociclib indirectly inhibits the functional activity of TBCCD1 by reducing the cellular demand for microtubule stabilization and dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A synthetic compound that disrupts microtubule polymerization. Nocodazole's interference with microtubule dynamics indirectly diminishes TBCCD1's role in stabilizing microtubules during the cell cycle. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A chemotherapy drug that stabilizes microtubules, preventing their disassembly. This stabilization indirectly diminishes the need for TBCCD1's role in microtubule dynamics by maintaining microtubules in a polymerized state. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
An alkaloid that binds to tubulin, inhibiting its polymerization into microtubules. Colchicine's action indirectly limits the functional activity of TBCCD1 by preventing the formation of the microtubules that TBCCD1 would normally stabilize. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
A synthetic analog of halichondrin B that inhibits microtubule growth. Eribulin's effect on microtubule dynamics indirectly leads to decreased functional activity of TBCCD1 due to reduced necessity for TBCCD1 in stabilizing microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
A toxin that inhibits the polymerization of tubulin into microtubules. By disrupting microtubule assembly, Podophyllotoxin indirectly diminishes the functional activity of TBCCD1 in microtubule stabilization. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
An antifungal agent that disrupts microtubule function by binding to tubulin. Griseofulvin's interference with microtubule assembly indirectly reduces TBCCD1's activity in stabilizing microtubules. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
An antifungal compound that also affects microtubule assembly. By perturbing microtubule function, Thiabendazole indirectly reduces the demand for TBCCD1's microtubule-stabilizing activity. | ||||||
Vinflunine | 162652-95-1 | sc-507411 | 10 mg | $390.00 | ||
A microtubule inhibitor that disrupts tubulin dynamics. Vinflunine's action indirectly lessens the need for TBCCD1's role in stabilizing microtubules by altering microtubule assembly. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
A compound that binds to tubulin and stabilizes microtubules. Laulimalide's stabilization of microtubules indirectly decreases the requirement for TBCCD1's microtubule-stabilizing function. | ||||||