TAZ Antibody (D-8): sc-518026
- TAZ Antibody (D-8) is a mouse monoclonal IgG1 κ, cited in 12 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 97-124 within an internal region of TAZ of human origin
- Anti-TAZ Antibody (D-8) is recommended for detection of TAZ of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TAZ Antibody (D-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TAZ Antibody (D-8). This work is in progress.
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SEE ALSO...
TAZ Antibody (D-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TAZ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAZ (D-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transcriptional co-activator with PDZ-binding motif (TAZ) plays a crucial role in cellular signaling and gene expression regulation, acting as a bridge between the plasma membrane and nucleus. TAZ interacts with the 14-3-3 protein family, which is essential for regulating various cellular processes such as differentiation, cell cycle progression, and apoptosis. The binding of 14-3-3 proteins to TAZ depends on phosphorylation of a specific serine residue (Serine 89), which modulates TAZ′s transcriptional co-activation capabilities and facilitates nuclear export, influencing gene expression outcomes. Anti-TAZ antibody (D-8) effectively recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3, and 293T cells, and works well with COS7, Hep G2, CHO, and HeLa cells expressing endogenous TAZ. TAZ functions as a transcriptional co-activator by binding to the PPXY motif on transcription factors, highlighting its significance in cellular signaling pathways and regulatory mechanisms in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAZ Antibody (D-8) | sc-518026 | 200 µg/ml | $316.00 | |||
TAZ Antibody (D-8) AC | sc-518026 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TAZ Antibody (D-8) HRP | sc-518026 HRP | 200 µg/ml | $316.00 | |||
TAZ Antibody (D-8) FITC | sc-518026 FITC | 200 µg/ml | $330.00 | |||
TAZ Antibody (D-8) PE | sc-518026 PE | 200 µg/ml | $343.00 | |||
TAZ Antibody (D-8) Alexa Fluor® 488 | sc-518026 AF488 | 200 µg/ml | $357.00 | |||
TAZ Antibody (D-8) Alexa Fluor® 546 | sc-518026 AF546 | 200 µg/ml | $357.00 | |||
TAZ Antibody (D-8) Alexa Fluor® 594 | sc-518026 AF594 | 200 µg/ml | $357.00 | |||
TAZ Antibody (D-8) Alexa Fluor® 647 | sc-518026 AF647 | 200 µg/ml | $357.00 | |||
TAZ Antibody (D-8) Alexa Fluor® 680 | sc-518026 AF680 | 200 µg/ml | $357.00 | |||
TAZ Antibody (D-8) Alexa Fluor® 790 | sc-518026 AF790 | 200 µg/ml | $357.00 |