Taxol Receptor Antibody (82H): sc-66021

Taxol Receptor Antibody (82H) is a mouse monoclonal IgG2b kappa light chain antibody that detects Taxol Receptor protein in mouse, rat, and human samples through immunoprecipitation (IP) and immunofluorescence (IF). Taxol Receptor (82H) antibody comes in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. Taxol Receptor, also known as β-tubulin receptor, regulates microtubule dynamics essential for cell division and function. When Taxol, a mitotic inhibitor from Pacific yew tree (Taxus brevifolia) bark, binds to Taxol Receptor, normal microtubule growth becomes disrupted, causing G2/M phase arrest and cancer cell apoptosis. This mechanism enables targeted destruction of rapidly dividing cells, making Taxol effective against ovarian, lung, breast, and prostate cancers. Taxol Receptor binding can lead to drug resistance and side effects like peripheral neurotoxicity, affecting large myelinated nerve fibers and causing motor and sensory dysfunction. Understanding Taxol Receptor function and interactions remains crucial for improving cancer treatment strategies and reducing adverse effects.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Taxol Receptor Antibody (82H) References:

1. Chemotherapy-induced peripheral neuropathy.  |  Hilkens, PH. and ven den Bent, MJ. 1997. J Peripher Nerv Syst. 2: 350-61. PMID: 10975744
2. The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density.  |  Snyder, JP., et al. 2001. Proc Natl Acad Sci U S A. 98: 5312-6. PMID: 11309480
3. Expression of beta-tubulin isotypes in human primary ovarian carcinoma.  |  Ohishi, Y., et al. 2007. Gynecol Oncol. 105: 586-92. PMID: 17343904
4. Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner.  |  Vellon, L., et al. 2007. Differentiation. 75: 819-30. PMID: 17999741
5. High-throughput screening of microtubule-interacting drugs.  |  Bane, SL., et al. 2007. Methods Mol Med. 137: 281-8. PMID: 18085236
6. Understanding tubulin/microtubule-taxane interactions: a quantitative structure-activity relationship study.  |  Hansch, C. and Verma, RP. 2008. Mol Pharm. 5: 151-61. PMID: 18171015
7. Microtubule-stabilizing natural products as promising cancer therapeutics.  |  Gallagher, BM. 2007. Curr Med Chem. 14: 2959-67. PMID: 18220732
8. Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity.  |  Callizot, N., et al. 2008. Cancer Chemother Pharmacol. 62: 995-1007. PMID: 18270703
9. Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes.  |  Xue, B., et al. 2020. Chem Biodivers. 17: e1900631. PMID: 31967396
10. A Compressive Review about Taxol®: History and Future Challenges.  |  Gallego-Jara, J., et al. 2020. Molecules. 25: PMID: 33348838
11. Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases.  |  Wang, T., et al. 2021. Molecules. 26: PMID: 34065782
12. Taxol neuropathy. Electrodiagnostic and sural nerve biopsy findings.  |  Sahenk, Z., et al. 1994. Arch Neurol. 51: 726-9. PMID: 7912506

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Taxol Receptor Antibody (82H) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Taxol Receptor Antibody (82H) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Taxol Receptor Antibody (82H) Specifications

Alternate Product Name: Taxol Receptor

Product Clone Name: 82H

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Taxol

Epitope Species:

Product Reactivity/Detection: the taxol binding site in tubulin-microtubule interactions

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Taxol Receptor Antibody (82H): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin