Tau Antibody (TAU-5): sc-58860

Tau Antibody (TAU-5) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize purified Tau protein of bovine origin, specifically targeting the C-terminus of human Tau. Tau monoclonal antibody (TAU-5) reliably detects both phosphorylated and non-phosphorylated Tau proteins from mouse, rat, human, and bovine sources across various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Tau, also known as MAPT (microtubule-associated protein tau), or TAU, is a 758 amino acid protein primarily located in the neuronal cytoplasm, cytoskeleton, and cell membrane. Tau′s main function is to stabilize microtubules, which are essential for maintaining the structural integrity of neurons and facilitating intracellular transport. By promoting microtubule assembly and stability, Tau plays a crucial role in maintaining neuronal polarity and supporting cytoskeletal plasticity, which are vital for proper neuronal function and connectivity. Tau (TAU-5) antibody exists in multiple alternatively spliced isoforms, allowing for diverse roles in neuronal health and adaptability. Tau undergoes various post-translational modifications, including phosphorylation, polyubiquitination, and glycation, which regulate activity and degradation, ensuring dynamic cytoskeletal dynamics. Dysregulation of Tau function and structure is associated with several neurodegenerative diseases, such as Alzheimer′s disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), highlighting importance in maintaining neuronal integrity and role in disease pathology. Available in a non-conjugated form, Tau (TAU-5) monoclonal antibody provides researchers with a dependable tool for investigating Tau′s role in cellular processes and neurodegenerative conditions.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tau Antibody (TAU-5) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-Tau Antibody (TAU-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tau Antibody (TAU-5) Specifications

Alternate Product Name: MAPT

Product Clone Name: TAU-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 210 - 241

Epitope Target: Tau

Epitope Species: bovine

Product Reactivity/Detection: both phosphorylated and non-phosphorylated Tau proteins

Species Reactivity/Detection: mouse, rat, human, bovine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for Tau Antibody (TAU-5): N/A

The preferred Tau antibody is Tau Antibody (Tau 46): sc-32274.