TATI Antibody (E-2): sc-374409

TATI Antibody (E-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects TATI protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TATI (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The tumor-associated trypsin inhibitor (TATI), also known as pancreatic secretory trypsin inhibitor, plays a crucial role in the pancreas by preventing the premature activation of zymogens through its single Kazal-like domain, thereby protecting pancreatic tissue from damage caused by trypsin. The gene encoding this 79 amino acid protein, SPINK1, is located on chromosome 5q32, and mutations in this gene are linked to chronic pancreatitis, an autosomal dominant condition characterized by severe abdominal pain and the formation of calculi in pancreatic ducts. Notably, TATI can be detected in the cyst fluid of patients with cystic pancreatic lesions, making TATI a valuable biomarker for distinguishing between benign and malignant cystic pancreatic lesions, which is essential for guiding appropriate clinical management.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TATI Antibody (E-2) References:

1. Cyst fluid tumor-associated trypsin inhibitor may be helpful in the differentiation of cystic pancreatic lesions.  |  Räty, S., et al. 2004. J Gastrointest Surg. 8: 569-74. PMID: 15239993
2. Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum.  |  Paju, A., et al. 2004. Clin Cancer Res. 10: 4761-8. PMID: 15269150
3. High tissue expression of tumour-associated trypsin inhibitor (TATI) associates with a more favourable prognosis in gastric cancer.  |  Wiksten, JP., et al. 2005. Histopathology. 46: 380-8. PMID: 15810949

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TATI Antibody (E-2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TATI Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TATI Antibody (E-2) Specifications

Alternate Product Name: TATI

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-72

Epitope Target: TATI

Epitope Species: human

Product Reactivity/Detection: TATI

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TATI Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin