TANK Antibody (B-12): sc-373923
- TANK Antibody (B-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-26 at the N-terminus of TANK of mouse origin
- recommended for detection of TANK of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TANK Antibody (B-12) for WB applications. These reagents are now offered in bundles with TANK Antibody (B-12) (see ordering information below).
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TANK Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects TANK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TANK, or TRAF family member-associated NF-kB activator, plays a crucial role in the regulation of the NF-kB signaling pathway, which is vital for immune response, inflammation, and cell survival. Located primarily in the cytoplasm, TANK interacts with TRAF proteins, particularly TRAF2, to modulate the activation of NF-kB. This interaction helps to control the cellular response to various stimuli, including cytokines and stress signals. The regulatory carboxy-terminal domain of TANK is essential for maintaining inactivity in unstimulated cells, ensuring that NF-kB activation occurs only when necessary. Anti-TANK antibody (B-12) enables researchers to explore the dynamics of NF-kB signaling and its implications in various diseases, including cancer and autoimmune disorders, thereby advancing our understanding of cellular signaling mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TANK Antibody (B-12) References:
- TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. | Bonif, M., et al. 2006. Biochem J. 394: 593-603. PMID: 16336209
- Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. | Gatot, JS., et al. 2007. J Biol Chem. 282: 31131-46. PMID: 17823124
- The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling. | Clark, K., et al. 2011. Proc Natl Acad Sci U S A. 108: 17093-8. PMID: 21949249
- TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. | Maruyama, K., et al. 2012. J Biol Chem. 287: 29114-24. PMID: 22773835
- TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. | Zhang, M., et al. 2012. J Exp Med. 209: 1703-11. PMID: 22945920
- TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function. | Wu, M., et al. 2012. Int J Biol Sci. 8: 1398-407. PMID: 23139637
- TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11. | Salerno, KM., et al. 2013. Neuroscience. 231: 28-37. PMID: 23201825
- The roles of grouper TANK in innate immune defense against iridovirus and nodavirus infections. | Wei, J., et al. 2020. Fish Shellfish Immunol. 104: 506-516. PMID: 32585359
- TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. | Huh, JY., et al. 2020. Cell Metab. 32: 1012-1027.e7. PMID: 33152322
- TANK shapes an immunosuppressive microenvironment and predicts prognosis and therapeutic response in glioma. | Li, S., et al. 2023. Front Immunol. 14: 1138203. PMID: 37215097
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TANK Antibody (B-12) | sc-373923 | 200 µg/ml | $316.00 | |||
TANK Antibody (B-12): m-IgG Fc BP-HRP Bundle | sc-540407 | 200 µg Ab; 10 µg BP | $354.00 | |||
TANK Antibody (B-12): m-IgG1 BP-HRP Bundle | sc-542099 | 200 µg Ab; 20 µg BP | $354.00 | |||
TANK (B-12) Neutralizing Peptide | sc-373923 P | 100 µg/0.5 ml | $68.00 |