TANC2 Antibody (D-11): sc-515710

TANC2 Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TANC2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TANC2 (D-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TANC2, also known as tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2, is a large 1,990 amino acid protein that plays a crucial role in cellular signaling and protein-protein interactions, particularly in neuronal development and synaptic function. TANC2′s structure includes eleven ankyrin repeats and three tetratricopeptide repeats, which are essential for mediating interactions with other proteins, thereby influencing various cellular processes. TANC2 is encoded on human chromosome 17q23.3, a region associated with key tumor suppressor genes such as p53 and BRCA1, both vital for maintaining genomic stability and preventing tumorigenesis. TANC2′s interactions with specific proteins involved in these pathways highlights its potential importance in cancer biology and neurodevelopmental disorders, making anti-TANC2 antibody (D-11) a valuable tool for researchers studying these critical areas.

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TANC2 Antibody (D-11) References:

1. p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis.  |  Soussi, T., et al. 2000. Hum Mutat. 15: 105-13. PMID: 10612830
2. Distinct pattern of p53 phosphorylation in human tumors.  |  Minamoto, T., et al. 2001. Oncogene. 20: 3341-7. PMID: 11423984
3. Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier.  |  Piura, B., et al. 2001. Eur J Obstet Gynecol Reprod Biol. 97: 241-4. PMID: 11451557
4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.  |  Brill, LM., et al. 2004. Anal Chem. 76: 2763-72. PMID: 15144186
5. Closing in on a breast cancer gene on chromosome 17q.  |  Hall, JM., et al. 1992. Am J Hum Genet. 50: 1235-42. PMID: 1598904
6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.  |  Mayya, V., et al. 2009. Sci Signal. 2: ra46. PMID: 19690332
7. Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.  |  Guo, H., et al. 2019. Nat Commun. 10: 4679. PMID: 31616000
8. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.  |  Kim, SG., et al. 2021. Nat Commun. 12: 2695. PMID: 33976205
9. Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.  |  Garrett, L., et al. 2022. Dis Model Mech. 15: PMID: 34964047
10. A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.  |  Varley, JM., et al. 1997. Oncogene. 14: 865-71. PMID: 9047394
11. The Li-Fraumeni syndrome: an inherited susceptibility to cancer.  |  Evans, SC. and Lozano, G. 1997. Mol Med Today. 3: 390-5. PMID: 9302689
12. Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix.  |  Kersemaekers, AM., et al. 1998. Br J Cancer. 77: 192-200. PMID: 9460988

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TANC2 Antibody (D-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TANC2 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TANC2 Antibody (D-11) Specifications

Alternate Product Name: TANC2

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1534-1737

Epitope Target: TANC2

Epitope Species: human

Product Reactivity/Detection: TANC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TANC2 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin