Talin Antibody (TLN01 [TA205]): sc-59882

Talin Antibody (TLN01 [TA205]) is a mouse monoclonal IgG1 antibody that detects Talin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Talin plays a crucial role in cell adhesion and signaling by linking integrins to the actin cytoskeleton, which is essential for maintaining the structural integrity of cells and facilitating communication with the extracellular matrix. This interaction is vital for processes such as cell migration, proliferation, and differentiation, making Talin (TLN01 [TA205]) antibody a key tool for studying tissue development and repair. Talin is primarily located at focal adhesions, where Talin acts as a molecular bridge that connects integrins to actin filaments, thereby influencing cellular responses to mechanical and biochemical signals. Talin′s ability to undergo post-translational modifications, such as phosphorylation, further regulates Talin activity and interactions with other proteins, including vinculin and α-actinin, which are also integral to the focal adhesion complex. The dynamic regulation of Talin and associated proteins is critical for proper cellular function and has implications in various diseases, including cancer and cardiovascular disorders, highlighting Talin′s importance in both health and disease.

The preferred Talin antibody is Talin Antibody (C-9): sc-365875.