TADA3L Antibody (D-10): sc-166118
- TADA3L Antibody (D-10) is a mouse monoclonal IgG1 κ TADA3L antibody provided at 200 µg/ml
- raised against amino acids 1-286 mapping at the N-terminus of TADA3L of human origin
- TADA3L Antibody (D-10) is recommended for detection of TADA3L of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TADA3L Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TADA3L Antibody (D-10) for WB applications. These reagents are now offered in bundles with TADA3L Antibody (D-10) (see ordering information below).
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TADA3L Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects TADA3L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TADA3L Antibody (D-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TADA3L protein, also known as transcriptional adapter 3-like or ADA3, is a crucial 432 amino acid nuclear protein that plays a significant role in transcriptional regulation as a component of the PCAF (p300/CBP-associated factor) complex, which is essential for histone acetylation in a nucleosomal context. This function is vital for the regulation of gene expression, as acetylation of histones can lead to a more relaxed chromatin structure, allowing for increased accessibility of transcriptional machinery to DNA. Additionally, TADA3L is part of the ATAC complex, which actively acetylates histones H3 and H4, further emphasizing TADA3L′s importance in chromatin remodeling and gene regulation. The gene encoding TADA3L is located on human chromosome 3, a region associated with various genetic diseases and key tumor suppressor genes, highlighting TADA3L′s potential implications in cancer biology and other genetic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TADA3L Antibody (D-10) References:
- The molecular genetics of Marfan syndrome and related microfibrillopathies. | Robinson, PN. and Godfrey, M. 2000. J Med Genet. 37: 9-25. PMID: 10633129
- Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. | Maho, A., et al. 1999. Cytogenet Cell Genet. 87: 265-8. PMID: 10702689
- [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification]. | Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
- Plasticity of human chromosome 3 during primate evolution. | Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
- Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution. | Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
- Methylation of the tumor suppressor gene RASSF1A in human tumors. | Pfeifer, GP. and Dammann, R. 2005. Biochemistry (Mosc). 70: 576-83. PMID: 15948711
- High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. | Nair, PN., et al. 2007. Cancer Genet Cytogenet. 174: 100-10. PMID: 17452250
- Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family. | De Jonghe, P., et al. 1997. J Neurol Neurosurg Psychiatry. 62: 570-3. PMID: 9219740
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TADA3L Antibody (D-10) | sc-166118 | 200 µg/ml | $316.00 | |||
TADA3L Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-528909 | 200 µg Ab; 10 µg BP | $354.00 | |||
TADA3L Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-521513 | 200 µg Ab, 40 µg BP | $354.00 | |||
TADA3L Antibody (D-10): m-IgG1 BP-HRP Bundle | sc-543204 | 200 µg Ab; 20 µg BP | $354.00 | |||
TADA3L Antibody (D-10) AC | sc-166118 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TADA3L Antibody (D-10) HRP | sc-166118 HRP | 200 µg/ml | $316.00 | |||
TADA3L Antibody (D-10) FITC | sc-166118 FITC | 200 µg/ml | $330.00 | |||
TADA3L Antibody (D-10) PE | sc-166118 PE | 200 µg/ml | $343.00 | |||
TADA3L Antibody (D-10) Alexa Fluor® 488 | sc-166118 AF488 | 200 µg/ml | $357.00 | |||
TADA3L Antibody (D-10) Alexa Fluor® 546 | sc-166118 AF546 | 200 µg/ml | $357.00 | |||
TADA3L Antibody (D-10) Alexa Fluor® 594 | sc-166118 AF594 | 200 µg/ml | $357.00 | |||
TADA3L Antibody (D-10) Alexa Fluor® 647 | sc-166118 AF647 | 200 µg/ml | $357.00 | |||
TADA3L Antibody (D-10) Alexa Fluor® 680 | sc-166118 AF680 | 200 µg/ml | $357.00 | |||
TADA3L Antibody (D-10) Alexa Fluor® 790 | sc-166118 AF790 | 200 µg/ml | $357.00 |