TACI Antibody (C-9): sc-365253

TACI Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects TACI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TACI (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TACI protein, or transmembrane activator and CAML-interactor, plays a crucial role in the immune system by mediating B cell activation and regulating immunoglobulin production. TACI (C-9) monoclonal antibody targets proteins primarily located on B cell surfaces, essential for signaling pathways that lead to B cell proliferation and differentiation. This localization enables TACI to interact with other proteins involved in immune responses, such as CAML, which enhances activation of nuclear factor of activated T cells (NFAT) and influences cytokine expression. TACI′s ability to modulate these pathways underscores its importance in maintaining immune homeostasis and responding to infections, making anti-TACI antibody (C-9) a valuable tool for researchers studying B cell biology and related immunological processes.

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TACI Antibody (C-9) References:

1. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.  |  Gross, JA., et al. 2000. Nature. 404: 995-9. PMID: 10801128
2. TACI expression and signaling in chronic lymphocytic leukemia.  |  Mamara, A., et al. 2015. J Immunol Res. 2015: 478753. PMID: 25950010
3. TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.  |  Jacobs, HM., et al. 2021. Eur J Immunol. 51: 2225-2236. PMID: 34146342
4. TNFRSF13B/TACI Mutations in Patients with Chronic Rhinosinusitis with Nasal Polyps.  |  Tsiouma, GK., et al. 2023. Am J Rhinol Allergy. 37: 74-77. PMID: 36305039
5. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.  |  Bram, RJ. and Crabtree, GR. 1994. Nature. 371: 355-8. PMID: 7522304
6. NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.  |  Ho, SN., et al. 1995. J Biol Chem. 270: 19898-907. PMID: 7650004
7. NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction.  |  Rao, A. 1995. J Leukoc Biol. 57: 536-42. PMID: 7722411
8. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.  |  Masuda, ES., et al. 1995. Mol Cell Biol. 15: 2697-706. PMID: 7739550
9. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.  |  Hoey, T., et al. 1995. Immunity. 2: 461-72. PMID: 7749981
10. Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.  |  Ho, S., et al. 1994. Adv Exp Med Biol. 365: 167-73. PMID: 7887301
11. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.  |  Timmerman, LA., et al. 1996. Nature. 383: 837-40. PMID: 8893011
12. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.  |  von Bülow, GU. and Bram, RJ. 1997. Science. 278: 138-41. PMID: 9311921

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TACI Antibody (C-9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TACI Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TACI Antibody (C-9) Specifications

Alternate Product Name: TACI

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 43-293

Epitope Target: TACI

Epitope Species: human

Product Reactivity/Detection: TACI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TACI Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin