SYP/Synaptophysin Antibody (SVP38): sc-12737

SYP Antibody (SVP38) is a mouse monoclonal IgG1 kappa light chain antibody that detects synaptophysin (SYP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-SYP antibody (SVP38) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Synaptophysin is an integral membrane protein predominantly located in synaptic vesicles of neurons and endocrine cells, where SYP plays a crucial role in the regulation of neurotransmitter release. SYP forms hexameric complexes, which are essential for maintaining the structure and function of synaptic vesicles. SYP is involved in the endocytosis and recycling of synaptic vesicles, a process vital for sustaining synaptic transmission and plasticity. SYP presence in early endosomes indicates a role in the trafficking and sorting of synaptic vesicle proteins, which is critical for neuronal communication. SYP interacts with other proteins such as synaptobrevin, contributing to the dynamic regulation of synaptic vesicle pools during neuronal development. SYP ability to form complexes with membrane cholesterol further underscores an importance in vesicle formation and function, highlighting significance in the intricate processes of synaptic transmission and neuronal signaling.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SYP/Synaptophysin Antibody (SVP38) has 28 citations in a variety of scientific publications.

Primary antibodies like Anti-SYP/Synaptophysin Antibody (SVP38) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SYP/Synaptophysin Antibody (SVP38) Specifications

Alternate Product Name: Synaptophysin

Product Clone Name: SVP38

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: SYP

Epitope Species: rat

Product Reactivity/Detection: SYP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 28 citations in various scientific publications

Available Conjugates/Forms for SYP/Synaptophysin Antibody (SVP38): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred SYP/Synaptophysin antibody is SYP/Synaptophysin Antibody (D-4): sc-17750.