SYP/Synaptophysin Antibody (4H255): sc-58301
- SYP/Synaptophysin Antibody (4H255) is a mouse monoclonal IgM κ, cited in 3 publications, provided at 200 µg/ml
- raised against synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates
- recommended for detection of SYP of mouse, rat, human and bovine origin by WB, IP, IF and IHC(P)
- See SYP/Synaptophysin (D-4): sc-17750 for SYP/Synaptophysin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SYP/Synaptophysin Antibody (4H255) for WB and IHC(P) applications. This reagent is now offered in a bundle with SYP/Synaptophysin Antibody (4H255) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
SYP Antibody (4H255) is a mouse monoclonal IgM antibody that detects synaptophysin (SYP) in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. SYP is an integral membrane protein predominantly found in neurons and endocrine cells, playing a crucial role in regulating synaptic vesicle dynamics. SYP forms hexameric complexes that contribute to large conductance channels, essential for neurotransmitter release and synaptic transmission. SYP contains four transmembrane domains and is N-glycosylated, important for stability and function within the membrane. SYP interacts with membrane cholesterol, facilitating vesicle formation and recycling, a process vital for maintaining synaptic function. SYP forms complexes with synaptobrevin (VAMP) and brain Myosin V, involved in neurotransmitter transport and release. The interaction between SYP and synaptobrevin is particularly significant during neuronal development, providing a reservoir of synaptobrevin for exocytosis, although not essential for the exocytosis process itself. Anti-SYP antibody (4H255) serves as an invaluable tool for researchers studying synaptic mechanisms and molecular underpinnings of neurotransmission.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SYP/Synaptophysin Antibody (4H255) | sc-58301 | 200 µg/ml | $322.00 | |||
SYP/Synaptophysin Antibody (4H255): m-IgGκ BP-HRP Bundle | sc-550734 | 200 µg Ab; 40 µg BP | $361.00 |