Syntaxin 3 Antibody (D-5): sc-393518

Syntaxin 3 Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Syntaxin 3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Syntaxin 3 antibody (D-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syntaxin 3 plays a crucial role in vesicular transport, essential for eukaryotic cell survival. Syntaxin 3 belongs to the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, vital for synaptic vesicle fusion with plasma membrane. Syntaxin 3 localizes to apical plasma membrane, participating in membrane fusion processes of apical trafficking pathways. Proper functioning of Syntaxin 3 is critical for neurite growth and serves as a direct target for arachidonic acid, highlighting significance in neuronal signaling and development. Human Syntaxin 3 exists in two forms, Syntaxin 3A and 3B, while mouse variants include four forms: 3A, 3B, 3C, and 3D, each contributing to diverse cellular processes.

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Syntaxin 3 Antibody (D-5) References:

1. Deployment of membrane fusion protein domains during fusion.  |  Bentz, J. and Mittal, A. 2000. Cell Biol Int. 24: 819-38. PMID: 11067767
2. Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5.  |  Watson, RT. and Pessin, JE. 2001. Am J Physiol Cell Physiol. 281: C215-23. PMID: 11401844
3. The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells.  |  ter Beest, MB., et al. 2005. Mol Biol Cell. 16: 5784-92. PMID: 16207812
4. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity.  |  Low, SH., et al. 2006. Mol Biol Cell. 17: 977-89. PMID: 16339081
5. Apical targeting of syntaxin 3 is essential for epithelial cell polarity.  |  Sharma, N., et al. 2006. J Cell Biol. 173: 937-48. PMID: 16785322
6. Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells.  |  Schillemans, M., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 1549-1561. PMID: 29880488
7. Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons.  |  Shi, S., et al. 2020. Sci Rep. 10: 709. PMID: 31959797
8. Syntaxin 3 interacts with serotonin transporter and regulates its function.  |  Motoike, S., et al. 2021. J Pharmacol Sci. 145: 297-307. PMID: 33712280
9. Syntaxin 3 is haplosufficient for long-term photoreceptor survival in the mouse retina.  |  Perez-Hurtado, M., et al. 2023. Front Ophthalmol (Lausanne). 3: PMID: 37609371
10. The syntaxin family of vesicular transport receptors.  |  Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
11. A v-SNARE implicated in intra-Golgi transport.  |  Nagahama, M., et al. 1996. J Cell Biol. 133: 507-16. PMID: 8636227
12. A SNARE involved in protein transport through the Golgi apparatus.  |  Lowe, SL., et al. 1997. Nature. 389: 881-4. PMID: 9349823

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Syntaxin 3 Antibody (D-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Syntaxin 3 Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Syntaxin 3 Antibody (D-5) Specifications

Alternate Product Name: Syntaxin 3

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-33

Epitope Target: Syntaxin 3

Epitope Species: human

Product Reactivity/Detection: Syntaxin 3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Syntaxin 3 Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin