Syntaxin 1 Antibody (SP6): sc-20036
- Syntaxin 1 Antibody (SP6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against synaptic vesicle-containing fractions of immunoprecipitated human brain homogenate
- recommended for detection of Syntaxin 1 of broad species origin by WB, IP and IF
- See Syntaxin 1 (HPC-1): sc-12736 for Syntaxin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Syntaxin 1 Antibody (SP6) for WB applications. These reagents are now offered in bundles with Syntaxin 1 Antibody (SP6) (see ordering information below).
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SEE ALSO...
Syntaxin 1 Antibody (SP6) is a mouse monoclonal IgG1 antibody that detects Syntaxin 1 across multiple species through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Syntaxin 1 plays a crucial role in vesicular transport, which is vital for eukaryotic cell function and survival. Syntaxin 1 primarily localizes on synaptic vesicle membranes and enables vesicle fusion with the plasma membrane, facilitating neurotransmitter release in neurons. Syntaxin 1 interacts with other SNARE proteins, including VAMP and SNAP-25, forming a stable SNARE complex that drives lipid bilayer fusion - a process essential for synaptic transmission and cellular communication. Syntaxin 1 and associated proteins maintain crucial functions in neuronal activity, hormone secretion, and muscle contraction. Anti-Syntaxin 1 antibody (SP6) serves as an invaluable tool for researchers studying these fundamental cellular biology processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Syntaxin 1 Antibody (SP6) References:
- Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. | Toonen, RF., et al. 2005. J Neurochem. 93: 1393-400. PMID: 15935055
- Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. | Khvotchev, M., et al. 2007. J Neurosci. 27: 12147-55. PMID: 17989281
- S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding. | Palmer, ZJ., et al. 2008. Biochem J. 413: 479-91. PMID: 18452404
- Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. | de Wit, H., et al. 2009. Cell. 138: 935-46. PMID: 19716167
- Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. | Han, GA., et al. 2011. Mol Biol Cell. 22: 4134-49. PMID: 21900502
- Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25. | Santos, TC., et al. 2017. J Neurosci. 37: 4525-4539. PMID: 28348137
- Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth. | Fuschini, G., et al. 2018. Oncotarget. 9: 35922-35940. PMID: 30542508
- Syntaxin 1: A Novel Robust Immunophenotypic Marker of Neuroendocrine Tumors. | Kővári, B., et al. 2020. Int J Mol Sci. 21: PMID: 32059362
- The panel of syntaxin 1 and insulinoma-associated protein 1 outperforms classic neuroendocrine markers in pulmonary neuroendocrine neoplasms. | Zombori, T., et al. 2021. APMIS. 129: 186-194. PMID: 33417719
- SNARE protein VAMP-2, but not syntaxin-1, SNAP-25 and synaptotagmin 1, expressed in perisynaptic astrocytic processes in the CA1 area of the rat hippocampus. | Hussain, S. and Davanger, S. 2023. Neuroreport. 34: 75-80. PMID: 36608162
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syntaxin 1 Antibody (SP6) | sc-20036 | 200 µg/ml | $322.00 | |||
Syntaxin 1 Antibody (SP6): m-IgG Fc BP-HRP Bundle | sc-536643 | 200 µg Ab; 10 µg BP | $361.00 | |||
Syntaxin 1 Antibody (SP6): m-IgGκ BP-HRP Bundle | sc-533801 | 200 µg Ab; 40 µg BP | $361.00 | |||
Syntaxin 1 Antibody (SP6): m-IgG1 BP-HRP Bundle | sc-544728 | 200 µg Ab; 20 µg BP | $361.00 |