Syntaphilin Antibody (F-4): sc-365606
- Syntaphilin Antibody (F-4) is a mouse monoclonal IgG1 κ Syntaphilin antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 9-37 near the N-terminus of Syntaphilin of human origin
- Syntaphilin Antibody (F-4) is recommended for detection of Syntaphilin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Syntaphilin Antibody (F-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Syntaphilin Antibody (F-4) for WB applications. These reagents are now offered in bundles with Syntaphilin Antibody (F-4) (see ordering information below).
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Syntaphilin Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Syntaphilin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Syntaphilin antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syntaphilin plays a crucial role in regulating synaptic vesicle exocytosis by competing with SNAP 25 for binding to Syntaxin 1, a key component of the SNARE complex. By sequestering free Syntaxin 1, Syntaphilin effectively inhibits SNARE complex assembly, which is essential for neurotransmitter release at synapses. This regulatory function is vital for maintaining proper synaptic transmission and plasticity, highlighting Syntaphilin′s importance in neuronal communication and overall brain function. Syntaphilin′s ability to modulate exocytosis underscores potential implications in neurological disorders where synaptic dysfunction is a hallmark.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Syntaphilin Antibody (F-4) References:
- Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. | Lao, G., et al. 2000. Neuron. 25: 191-201. PMID: 10707983
- The syntaxin family of vesicular transport receptors. | Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
- Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. | Edelmann, L., et al. 1995. EMBO J. 14: 224-31. PMID: 7835333
- Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site. | McMahon, HT. and Südhof, TC. 1995. J Biol Chem. 270: 2213-7. PMID: 7836452
- Exocytosis relating proteins in the nervous system. | Yamaguchi, K. and Akagawa, K. 1994. Neurosci Res. 20: 289-92. PMID: 7870381
- Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. | Hayashi, T., et al. 1994. EMBO J. 13: 5051-61. PMID: 7957071
- A role for synaptotagmin (p65) in regulated exocytosis. | Elferink, LA., et al. 1993. Cell. 72: 153-9. PMID: 8422678
- Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. | Barnard, RJ., et al. 1997. J Cell Biol. 139: 875-83. PMID: 9362506
- Structural organization of the synaptic exocytosis core complex. | Lin, RC. and Scheller, RH. 1997. Neuron. 19: 1087-94. PMID: 9390521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syntaphilin Antibody (F-4) | sc-365606 | 200 µg/ml | $322.00 | |||
Syntaphilin Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-529406 | 200 µg Ab; 10 µg BP | $361.00 | |||
Syntaphilin Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-522289 | 200 µg Ab, 40 µg BP | $361.00 | |||
Syntaphilin Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-543500 | 200 µg Ab; 20 µg BP | $361.00 | |||
Syntaphilin Antibody (F-4) AC | sc-365606 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Syntaphilin Antibody (F-4) HRP | sc-365606 HRP | 200 µg/ml | $322.00 | |||
Syntaphilin Antibody (F-4) FITC | sc-365606 FITC | 200 µg/ml | $336.00 | |||
Syntaphilin Antibody (F-4) PE | sc-365606 PE | 200 µg/ml | $349.00 | |||
Syntaphilin Antibody (F-4) Alexa Fluor® 488 | sc-365606 AF488 | 200 µg/ml | $364.00 | |||
Syntaphilin Antibody (F-4) Alexa Fluor® 546 | sc-365606 AF546 | 200 µg/ml | $364.00 | |||
Syntaphilin Antibody (F-4) Alexa Fluor® 594 | sc-365606 AF594 | 200 µg/ml | $364.00 | |||
Syntaphilin Antibody (F-4) Alexa Fluor® 647 | sc-365606 AF647 | 200 µg/ml | $364.00 | |||
Syntaphilin Antibody (F-4) Alexa Fluor® 680 | sc-365606 AF680 | 200 µg/ml | $364.00 | |||
Syntaphilin Antibody (F-4) Alexa Fluor® 790 | sc-365606 AF790 | 200 µg/ml | $364.00 | |||
Syntaphilin (F-4) Neutralizing Peptide | sc-365606 P | 100 µg/0.5 ml | $69.00 |