Syntaphilin Inhibitors
Syntaphilin inhibitors represent a chemical class of compounds that primarily target a specific protein known as syntaphilin. Syntaphilin, also referred to as SNAPIN or Synaptotagmin-associated protein, is a crucial regulator of mitochondrial transport within neurons. Mitochondria are organelles responsible for generating energy in the form of adenosine triphosphate (ATP), and their proper distribution within neurons is vital for the maintenance of neuronal health and function. Syntaphilin normally acts as a tethering protein, anchoring mitochondria to microtubules and hindering their mobility within axons. This tethering process helps to regulate mitochondrial distribution and maintain energy balance in neurons.Syntaphilin inhibitors are designed to disrupt this interaction between syntaphilin and microtubules, thereby promoting the movement of mitochondria along axons. By inhibiting syntaphilin, these compounds facilitate the dynamic transport of mitochondria to regions of high energy demand within neurons, such as synapses.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
A selective inhibitor of the mitochondrial division protein Drp1, which may indirectly affect SNPH's regulatory role. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Inhibits mitochondrial permeability transition pore (mPTP), potentially affecting SNPH-related mitochondrial function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Targets ATP synthase and may affect mitochondrial dynamics, indirectly influencing SNPH activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Inhibits mitochondrial complex I, which could alter mitochondrial function and indirectly affect SNPH. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Inhibits mitochondrial complex III, possibly affecting mitochondrial dynamics and SNPH function. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
Uncouples oxidative phosphorylation, potentially influencing SNPH by altering mitochondrial dynamics. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Inhibits dynamin, a GTPase involved in mitochondrial fission, which may indirectly affect SNPH. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
Another uncoupler of oxidative phosphorylation, potentially affecting SNPH by altering mitochondrial dynamics. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
May influence mitochondrial biogenesis and dynamics, potentially impacting SNPH function indirectly. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Activates AMPK, which can influence mitochondrial dynamics, potentially affecting SNPH activity indirectly. | ||||||