synphilin-1 Antibody (F-9): sc-365741
- synphilin-1 Antibody (F-9) is a mouse monoclonal IgG1 κ synphilin-1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of synphilin-1 of human origin
- synphilin-1 Antibody (F-9) is recommended for detection of synphilin-1 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-synphilin-1 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for synphilin-1 Antibody (F-9) for WB applications. These reagents are now offered in bundles with synphilin-1 Antibody (F-9) (see ordering information below).
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SEE ALSO...
synphilin-1 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects synphilin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). synphilin-1 Antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. synphilin-1, also known as alpha synuclein interacting protein (SNCAIP), is a 919-amino acid protein that plays a crucial role in the pathogenesis of neurodegenerative diseases by interacting with alpha-synuclein and facilitating the formation of cytosolic inclusions in neuronal cells. This interaction is particularly significant in Parkinson′s disease, where synphilin-1 and alpha-synuclein are co-expressed in Lewy bodies, contributing to disease progression. The presence of modular protein domains in synphilin-1, such as ankyrin-like repeats and a coiled-coil domain, is essential for function and interactions, as these structural features enable engagement with other cellular components effectively. Understanding synphilin-1 dynamics and interactions is vital for elucidating molecular mechanisms underlying synaptic regulation and neuronal plasticity, which are critical for maintaining healthy brain function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
synphilin-1 Antibody (F-9) References:
- Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. | Engelender, S., et al. 1999. Nat Genet. 22: 110-4. PMID: 10319874
- Synphilin-1 is present in Lewy bodies in Parkinson's disease. | Wakabayashi, K., et al. 2000. Ann Neurol. 47: 521-3. PMID: 10762166
- Genetic analysis of synphilin-1 in familial Parkinson's disease. | Farrer, M., et al. 2001. Neurobiol Dis. 8: 317-23. PMID: 11300726
- Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. | Kawamata, H., et al. 2001. J Neurochem. 77: 929-34. PMID: 11331421
- Identification of two distinct synucleins from human brain. | Jakes, R., et al. 1994. FEBS Lett. 345: 27-32. PMID: 8194594
- Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. | Uéda, K., et al. 1993. Proc Natl Acad Sci U S A. 90: 11282-6. PMID: 8248242
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
synphilin-1 Antibody (F-9) | sc-365741 | 200 µg/ml | $322.00 | |||
synphilin-1 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-529452 | 200 µg Ab; 10 µg BP | $361.00 | |||
synphilin-1 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-522348 | 200 µg Ab, 40 µg BP | $361.00 | |||
synphilin-1 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-543523 | 200 µg Ab; 20 µg BP | $361.00 | |||
synphilin-1 Antibody (F-9) AC | sc-365741 AC | 500 µg/ml, 25% agarose | $424.00 | |||
synphilin-1 Antibody (F-9) HRP | sc-365741 HRP | 200 µg/ml | $322.00 | |||
synphilin-1 Antibody (F-9) FITC | sc-365741 FITC | 200 µg/ml | $336.00 | |||
synphilin-1 Antibody (F-9) PE | sc-365741 PE | 200 µg/ml | $349.00 | |||
synphilin-1 Antibody (F-9) Alexa Fluor® 488 | sc-365741 AF488 | 200 µg/ml | $364.00 | |||
synphilin-1 Antibody (F-9) Alexa Fluor® 546 | sc-365741 AF546 | 200 µg/ml | $364.00 | |||
synphilin-1 Antibody (F-9) Alexa Fluor® 594 | sc-365741 AF594 | 200 µg/ml | $364.00 | |||
synphilin-1 Antibody (F-9) Alexa Fluor® 647 | sc-365741 AF647 | 200 µg/ml | $364.00 | |||
synphilin-1 Antibody (F-9) Alexa Fluor® 680 | sc-365741 AF680 | 200 µg/ml | $364.00 | |||
synphilin-1 Antibody (F-9) Alexa Fluor® 790 | sc-365741 AF790 | 200 µg/ml | $364.00 |