SYND4/SDC4/Syndecan-4 Antibody (5G9): sc-12766

Syndecan-4 Antibody (5G9) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect Syndecan-4, also known as amphiglycan or ryudocan, across mouse, rat, and human species. Raised against the human Syndecan-4 epitope, anti-Syndecan-4 antibody (5G9) is versatile for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Syndecan-4 is a type I integral membrane proteoglycan that plays a pivotal role in cell-extracellular matrix adhesion, collaborating with integrins to facilitate cell spreading, focal adhesion assembly, and actin stress fiber formation. These functions are critical for processes such as cell migration, tissue repair, and signal transduction, highlighting the importance of Syndecan-4 in maintaining cellular structure and communication. Syndecan-4 monoclonal antibody (5G9) is available in both non-conjugated form and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing flexibility for diverse experimental needs. By targeting Syndecan-4, researchers can explore its involvement in key physiological and pathological mechanisms, including cancer metastasis, wound healing, and developmental biology. Anti-Syndecan-4 antibody (5G9) is an essential tool for studying the complex interactions and functions of Syndecan-4 in different biological contexts.

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SYND4/SDC4/Syndecan-4 Antibody (5G9) References:

1. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers.  |  Saoncella, S., et al. 1999. Proc Natl Acad Sci U S A. 96: 2805-10. PMID: 10077592
2. Adhesion of B lymphoid (MPC-11) cells to type I collagen is mediated by integral membrane proteoglycan, syndecan.  |  Sanderson, RD., et al. 1992. J Immunol. 148: 3902-11. PMID: 1602136
3. Syndecan family of cell surface proteoglycans: developmentally regulated receptors for extracellular effector molecules.  |  Salmivirta, M. and Jalkanen, M. 1995. Experientia. 51: 863-72. PMID: 7556568
4. Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development.  |  David, G., et al. 1993. Development. 119: 841-54. PMID: 8187643
5. Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine.  |  Nakanishi, T., et al. 1997. J Biochem. 121: 197-205. PMID: 9089390

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SYND4/SDC4/Syndecan-4 Antibody (5G9) has 99 citations in a variety of scientific publications.

Primary antibodies like Anti-SYND4/SDC4/Syndecan-4 Antibody (5G9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SYND4/SDC4/Syndecan-4 Antibody (5G9) Specifications

Alternate Product Name: Syndecan-4

Product Clone Name: 5G9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Syndecan-4

Epitope Species: human

Product Reactivity/Detection: the ectodomain of Syndecan-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 99 citations in various scientific publications

Available Conjugates/Forms for SYND4/SDC4/Syndecan-4 Antibody (5G9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin