SYND3/SDC3/Syndecan-3 Antibody (G-2): sc-398194

Syndecan-3 Antibody (G-2) is a mouse monoclonal IgM antibody that detects Syndecan-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Syndecan-3 antibody (G-2) is available as a non-conjugated format. Syndecan-3, also known as N-Syndecan, plays a crucial role in cell signaling and communication by acting as a co-receptor for various growth factors, including midkine, which is essential for the development of the central nervous system. This interaction regulates cellular processes such as proliferation, migration, and differentiation, particularly during embryogenesis. Heparan sulfate chains on Syndecan-3 enhance binding to growth factors and extracellular matrix components, thereby influencing cell behavior and tissue organization. Syndecan-3 also modulates cell-extracellular matrix adhesion, which maintains tissue integrity and facilitates cellular responses to environmental cues. With diverse functions and interactions, Syndecan-3 serves as an important protein in developmental biology and tissue homeostasis, making anti-Syndecan-3 antibody (G-2) a valuable research tool for studying these processes.

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SYND3/SDC3/Syndecan-3 Antibody (G-2) References:

1. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers.  |  Saoncella, S., et al. 1999. Proc Natl Acad Sci U S A. 96: 2805-10. PMID: 10077592
2. Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis.  |  Pacifici, M., et al. 2005. J Bone Miner Metab. 23: 191-9. PMID: 15838620
3. Adhesion of B lymphoid (MPC-11) cells to type I collagen is mediated by integral membrane proteoglycan, syndecan.  |  Sanderson, RD., et al. 1992. J Immunol. 148: 3902-11. PMID: 1602136
4. Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice.  |  Kehoe, O., et al. 2014. Arthritis Res Ther. 16: R148. PMID: 25015005
5. Syndecan-3 in Inflammation and Angiogenesis.  |  Arokiasamy, S., et al. 2019. Front Immunol. 10: 3031. PMID: 31998313
6. Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment.  |  Prieto-Fernández, E., et al. 2020. Front Immunol. 11: 586977. PMID: 33117401
7. Syndecan-3 enhances anabolic bone formation through WNT signaling.  |  Johnson de Sousa Brito, FM., et al. 2021. FASEB J. 35: e21246. PMID: 33769615
8. Syndecan-3 as a Novel Biomarker in Alzheimer's Disease.  |  Hudák, A., et al. 2022. Int J Mol Sci. 23: PMID: 35328830
9. The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes Ovarian Cancer Pathogenesis.  |  Hillemeyer, L., et al. 2022. Int J Mol Sci. 23: PMID: 35628603
10. Syndecan family of cell surface proteoglycans: developmentally regulated receptors for extracellular effector molecules.  |  Salmivirta, M. and Jalkanen, M. 1995. Experientia. 51: 863-72. PMID: 7556568
11. Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development.  |  David, G., et al. 1993. Development. 119: 841-54. PMID: 8187643
12. Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine.  |  Nakanishi, T., et al. 1997. J Biochem. 121: 197-205. PMID: 9089390

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SYND3/SDC3/Syndecan-3 Antibody (G-2) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SYND3/SDC3/Syndecan-3 Antibody (G-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SYND3/SDC3/Syndecan-3 Antibody (G-2) Specifications

Alternate Product Name: Syndecan-3

Product Clone Name: G-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 64-91

Epitope Target: syndecan-3

Epitope Species: rat

Product Reactivity/Detection: Syndecan-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SYND3/SDC3/Syndecan-3 Antibody (G-2): P: Blocking Peptide