Syndecan-3 Activators
Syndecan-3, a member of the syndecan family of transmembrane heparan sulfate proteoglycans, plays multifaceted roles in various cellular processes, particularly in cell-cell and cell-matrix interactions, cell signaling, and cell adhesion. Its expression is predominantly observed in the nervous system, where it contributes to neuronal development, synaptic plasticity, and axon guidance. Syndecan-3 is also involved in regulating cell proliferation, differentiation, and migration in diverse tissues and organs, including the skeletal muscle, adipose tissue, and pancreas. Through its interaction with extracellular matrix components and growth factors, Syndecan-3 modulates various signaling pathways such as the Wnt, FGF, and TGF-β pathways, thereby influencing cell fate determination and tissue homeostasis.
Activation of Syndecan-3 typically involves complex processes that entail the binding of extracellular ligands to its heparan sulfate chains, leading to conformational changes and subsequent intracellular signaling cascades. These ligands can include growth factors, cytokines, and ECM molecules, which bind to specific domains of Syndecan-3 and induce downstream signaling events. Activation of Syndecan-3 often results in the recruitment and activation of intracellular signaling molecules such as protein kinases and phosphatases, which in turn regulate gene expression, cytoskeletal dynamics, and cell migration. Moreover, Syndecan-3 activation can also promote the clustering of cell surface receptors and the formation of signaling complexes, amplifying the cellular response to extracellular stimuli. Overall, the activation of Syndecan-3 orchestrates a diverse array of cellular processes essential for tissue development, homeostasis, and adaptation to environmental cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a derivative of vitamin A, is implicated in the activation of Syndecan-3 through the regulation of gene expression. Retinoic Acid influences cellular processes related to cell adhesion and migration by modulating Syndecan-3 levels. Its effect on Syndecan-3 expression can impact downstream signaling pathways, contributing to the activation of cellular responses associated with Syndecan-3 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride, a compound known for its involvement in Wnt signaling, indirectly activates Syndecan-3 through the modulation of the Wnt pathway. Lithium Chloride inhibits glycogen synthase kinase-3 (GSK-3), a key regulator of the Wnt pathway. The inhibition of GSK-3 can lead to the stabilization and activation of β-catenin, which, in turn, influences Syndecan-3 expression and function. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetylcysteine, a precursor of glutathione, activates Syndecan-3 by influencing redox signaling. Redox-sensitive pathways, including those related to Syndecan-3, can be modulated by N-acetylcysteine. Its role in maintaining cellular redox balance can impact Syndecan-3-mediated cellular responses, including adhesion and migration. N-acetylcysteine's activation of Syndecan-3 highlights the intricate relationship between cellular redox status and the regulation of Syndecan-3 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a phorbol ester and activator of protein kinase C (PKC), can activate Syndecan-3 through the PKC pathway. Activation of PKC by PMA leads to the phosphorylation of Syndecan-3 and modulation of downstream signaling cascades associated with cell adhesion and migration. PMA's specific activation of Syndecan-3 through PKC highlights its role in promoting cellular responses associated with Syndecan-3-mediated functions. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone, a thiazolidinedione and agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ), can indirectly activate Syndecan-3 by modulating gene expression. PPAR-γ activation by Troglitazone influences cellular processes related to adhesion and migration by regulating Syndecan-3 levels. Its effect on Syndecan-3 expression can impact downstream signaling pathways, contributing to the activation of cellular responses associated with Syndecan-3 function. | ||||||
NOC-18 | 146724-94-9 | sc-202247 sc-202247A sc-202247B sc-202247C | 10 mg 50 mg 100 mg 500 mg | $51.00 $184.00 $305.00 $1122.00 | 18 | |
NOC-18, a nitric oxide donor, activates Syndecan-3 through nitric oxide signaling. Nitric oxide influences cellular processes related to cell adhesion and migration by modulating Syndecan-3 expression and function. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin, a serine protease, can activate Syndecan-3 by cleaving its extracellular domain. This proteolytic activation triggers downstream signaling events, including the activation of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) pathways, modulating cellular processes such as adhesion and migration. Thrombin's activation of Syndecan-3 through proteolytic cleavage highlights the dynamic regulation of Syndecan-3 function in response to specific extracellular cues. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Ob (hBA-147) activates Syndecan-3 by binding to its extracellular domain. This interaction triggers downstream signaling events, including the activation of phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways, modulating cellular processes such as adhesion and migration. Leptin's specific activation of Syndecan-3 highlights its role in promoting cellular responses associated with Syndecan-3-mediated functions. | ||||||