Synaptotagmin IX Antibody (E-11): sc-398592

Synaptotagmin IX Antibody (E-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Synaptotagmin IX of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Synaptotagmin IX antibody (E-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Synaptotagmin IX, also known as SYT9, is a 491 amino acid protein that plays a crucial role in calcium-dependent exocytosis of secretory vesicles, acting as a calcium sensor during vesicular trafficking. SYT9 is primarily located in synaptic vesicle membranes, vital for neurotransmitter release. Synaptotagmin IX at the synapse allows for rapid and precise signaling, essential for effective communication between neurons. SYT9 contains two C2 domains that enable binding of up to three calcium ions per subunit, facilitating norepinephrine and other neurotransmitter release. Synaptotagmin IX interactions with various proteins involved in synaptic transmission underscore SYT9′s importance in maintaining synaptic integrity and function, making Synaptotagmin IX a valuable target for research in neurobiology and related fields.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Synaptotagmin IX Antibody (E-11) References:

1. SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.  |  Mizutani, A., et al. 2000. J Biol Chem. 275: 9823-31. PMID: 10734137
2. Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells.  |  Fukuda, M., et al. 2002. J Biol Chem. 277: 4601-4. PMID: 11751925
3. Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis.  |  Zhang, X., et al. 2002. Neuron. 34: 599-611. PMID: 12062043
4. Identification of casein kinase Ialpha interacting protein partners.  |  Dubois, T., et al. 2002. FEBS Lett. 517: 167-71. PMID: 12062430
5. Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules.  |  Haberman, Y., et al. 2003. J Cell Sci. 116: 4307-18. PMID: 12966166
6. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity.  |  Morenilla-Palao, C., et al. 2004. J Biol Chem. 279: 25665-72. PMID: 15066994
7. The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.  |  Monies, D., et al. 2017. Hum Genet. 136: 921-939. PMID: 28600779
8. Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.  |  Seibert, MJ., et al. 2023. J Neurosci. 43: 1475-1491. PMID: 36732068
9. The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.  |  Zhang, M., et al. 2023. J Neurosci. 43: 3009-3027. PMID: 36898834
10. SYNAPTOTAGMIN-9 IN MOUSE RETINA.  |  Mesnard, CS., et al. 2024. bioRxiv.. PMID: 37425946
11. Synaptotagmin-9 in mouse retina.  |  Mesnard, CS., et al. 2024. Vis Neurosci. 41: E003. PMID: 39291699
12. Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.  |  Perin, MS. 1996. Biochemistry. 35: 13808-16. PMID: 8901523

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Synaptotagmin IX Antibody (E-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Synaptotagmin IX Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Synaptotagmin IX Antibody (E-11) Specifications

Alternate Product Name: Synaptotagmin IX

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 77-131

Epitope Target: Synaptotagmin IX

Epitope Species: human

Product Reactivity/Detection: Synaptotagmin IX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Synaptotagmin IX Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin