Synaptoporin Antibody (F-1): sc-398921

Synaptoporin Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects synaptoporin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Synaptoporin, also known as synaptophysin 2, plays a crucial role in synaptic vesicle recycling, a process essential for neurotransmitter release and communication between neurons. This integral membrane protein is primarily located in small synaptic vesicles and is highly homologous to synaptophysin 1, sharing a similar structure that includes four transmembrane domains and a short cytoplasmic tail. The presence of a MARVEL domain within synaptoporin is significant as this facilitates membrane association, while calcium-binding activity, localized to the cytoplasmic tail, is vital for regulating synaptic vesicle dynamics. By competing with SNARE complex components, synaptoporin, along with synaptophysin and syntaphilin, modulates the assembly and secretion of synaptic vesicles, thereby influencing synaptic transmission and plasticity. Anti-synaptoporin antibody (F-1) serves as an invaluable tool for researchers studying synaptic function and the molecular mechanisms underlying neurotransmission.

The preferred Synaptoporin antibody is Synaptoporin Antibody (C-9): sc-376761.