Synaptoporin Activators
Synaptoporin Activators encompass a variety of chemical compounds that indirectly enhance the functional activity of Synaptoporin, a protein critical in synaptic vesicle trafficking and neurotransmitter release. Forskolin, by increasing intracellular cAMP levels, activates PKA, which in turn can enhance Synaptoporin's role in synaptic vesicle dynamics. Similarly, the cAMP analog 8-Bromo-cAMP and the phosphodiesterase inhibitors Rolipram and Cilostazol elevate cAMP levels, thereby indirectly promoting Synaptoporin's functionality through PKA activation. The involvement of PKC in synaptic vesicle dynamics is highlighted by PMA, which can potentially enhance Synaptoporin's activity by phosphorylating associated proteins. Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) contribute to this network by activating TrkB and TrkA receptors, respectively. Their downstream signaling pathways play a vital role in synaptic plasticity, indirectly supporting Synaptoporin's function in synaptic vesicle trafficking.
Further contributing to the modulation of Synaptoporin's activity are compounds that influence cGMP levels and calcium signaling. Both Sildenafil and Tadalafil, as PDE-5 inhibitors, increase cGMP levels, potentially enhancing PKG activity, which in turn could support Synaptoporin's role in neurotransmitter release and synaptic function. Ionomycin, by increasing intracellular calcium levels, activates calcium-dependent kinases and phosphatases, offering another pathway to potentially enhance Synaptoporin's involvement in synaptic vesicle exocytosis. Additionally, FTY720, a sphingosine-1-phosphate receptor modulator, influences neuronal signaling pathways and could indirectly support Synaptoporin's functionality in synaptic processes. Collectively, these Synaptoporin Activators, through their targeted effects on various signaling pathways, play a crucial role in modulating the synaptic functions associated with Synaptoporin, highlighting the intricate interplay of biochemical pathways in neuronal communication and plasticity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA. PKA phosphorylation can enhance Synaptoporin's involvement in synaptic vesicle trafficking and neurotransmitter release. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog mimics the action of endogenous cAMP and can activate PKA, indirectly enhancing Synaptoporin's role in synaptic vesicle exocytosis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which can phosphorylate proteins involved in synaptic vesicle dynamics, potentially enhancing Synaptoporin's functionality in this process. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
As a selective phosphodiesterase-4 inhibitor, Rolipram elevates intracellular cAMP, enhancing PKA activity, which can indirectly support Synaptoporin in synaptic vesicle trafficking. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol inhibits phosphodiesterase-3, increasing cAMP levels. This elevation can enhance PKA activity, indirectly supporting Synaptoporin's role in synaptic vesicle dynamics. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits phosphodiesterase-1, increasing cAMP and cGMP levels, potentially supporting the functional role of Synaptoporin in synaptic vesicle trafficking. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil, another PDE-5 inhibitor, also increases cGMP levels, potentially enhancing PKG activity and indirectly supporting Synaptoporin's role in synaptic function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases and phosphatases, potentially enhancing Synaptoporin's role in synaptic vesicle exocytosis. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720, a sphingosine-1-phosphate receptor modulator, can influence neuronal signaling pathways, potentially supporting Synaptoporin's involvement in synaptic function. | ||||||