Synapsin Ia/b Antibody (A-1): sc-398849
- Synapsin Ia/b Antibody (A-1) is a mouse monoclonal IgM κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 662-686 at the C-terminus of Synapsin Ia/b of human origin
- recommended for detection of Synapsin Ia/b of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Synapsin Ia/b Antibody (A-1) for WB applications. This reagent is now offered in a bundle with Synapsin Ia/b Antibody (A-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Synapsin Ia/b Antibody (A-1) is a mouse monoclonal IgM antibody that detects Synapsin Ia/b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Synapsin Ia/b is a critical component of synaptic vesicle-associated phosphoproteins that play a vital role in regulating synaptic vesicle exocytosis and facilitating synaptogenesis. Synapsin Ia/b is primarily located in presynaptic terminals of neurons, where anti-Synapsin Ia/b antibody (A-1) helps detect maintenance of reserve pool synaptic vesicles and neurotransmitter release. Proper localization of Synapsin Ia/b is crucial for synaptic plasticity and overall neuronal communication, as Synapsin Ia/b helps tether synaptic vesicles to cytoskeleton and modulates availability for exocytosis in response to calcium signaling. Synapsin Ia/b undergoes alternative splicing, resulting in distinct isoforms that may have specialized functions in different neuronal contexts. Synapsin Ia/b monoclonal antibody (A-1) serves as an invaluable tool for researchers studying synaptic function and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders.
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Synapsin Ia/b Antibody (A-1) References:
- Synapsin I is a microtubule-bundling protein. | Baines, AJ. and Bennett, V. Nature. 319: 145-7. PMID: 2417124
- SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation. | Tang, LT., et al. 2015. Nat Commun. 6: 7728. PMID: 26173895
- Functional distribution of synapsin I in human sperm. | Coleman, WL., et al. 2015. FEBS Open Bio. 5: 801-8. PMID: 26566474
- Increased synapsin I expression in cerebral malaria. | Thonsranoi, K., et al. 2015. Int J Clin Exp Pathol. 8: 13996-4004. PMID: 26823711
- Synapsin I Synchronizes GABA Release in Distinct Interneuron Subpopulations. | Forte, N., et al. 2020. Cereb Cortex. 30: 1393-1406. PMID: 31504258
- Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release. | Yu, SC., et al. 2021. J Neurosci. 41: 4187-4201. PMID: 33820857
- Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation. | Polishchuk, A., et al. 2023. Cell Mol Biol Lett. 28: 17. PMID: 36869288
- The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice. | Bruentgens, F., et al. 2024. eNeuro. 11: PMID: 38866497
- Condensates of synaptic vesicles and synapsin are molecular beacons for actin sequestering and polymerization. | Akshita, C., et al. 2024. bioRxiv.. PMID: 39071264
- Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway. | Qurban, A., et al. 2025. Front Biosci (Landmark Ed). 30: 27111. PMID: 39862102
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synapsin Ia/b Antibody (A-1) | sc-398849 | 200 µg/ml | $322.00 | |||
Synapsin Ia/b Antibody (A-1): m-IgGκ BP-HRP Bundle | sc-524505 | 200 µg Ab, 40 µg BP | $361.00 | |||
Synapsin Ia/b (A-1) Neutralizing Peptide | sc-398849 P | 100 µg/0.5 ml | $69.00 |