SWAP-70 Antibody (Q-28): sc-81991
- SWAP-70 Antibody (Q-28) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against recombinant SWAP-70 of human origin
- recommended for detection of SWAP-70 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SWAP-70 Antibody (Q-28). This work is in progress.
QUICK LINKS
SEE ALSO...
SWAP-70 Antibody (Q-28) is a mouse monoclonal IgG2a antibody that detects SWAP-70 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SWAP-70 plays a crucial role in the immune response by facilitating the recombination of immunoglobulin heavy chain genes, which is essential for generating diverse antibodies necessary for effective immune defense. SWAP-70 is primarily localized in the cytoplasm of resting B lymphocytes, but upon activation, translocates to the plasma membrane and subsequently to the nucleus, where SWAP-70 acts as a switch recombinase, inducing DNA breaks at specific switch regions. This dynamic localization underscores SWAP-70′s importance in B cell signaling and activation, enabling participation in the regulation of gene expression during immune responses. Additionally, SWAP-70 contains three nuclear localization signals, exhibits a weak affinity for DNA, binds ATP, and forms high-affinity complexes with proteins such as B23, C23, and poly (ADP-ribose) polymerase, further highlighting SWAP-70′s multifaceted role in cellular processes. Anti-SWAP-70 antibody (Q-28) is an invaluable tool for researchers studying B cell biology and the mechanisms underlying immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SWAP-70 Antibody (Q-28) | sc-81991 | 50 µg/0.5 ml | $339.00 |