SV40 T Ag Antibody (Pab 108): sc-148
- SV40 T Ag Antibody (Pab 108) is a mouse monoclonal IgG2a κ, cited in 61 publications, provided at 200 µg/ml
- raised against SV-40 transformed cell line B4 of mouse origin
- SV40 T Ag Antibody (Pab 108) is recommended for detection of the N-terminus of large SV40 T antigen, small SV40 T antigen and BK virus T antigen of SV40 origin by WB, IP, IF and IHC(P)
- Anti-SV40 T Ag Antibody (Pab 108) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for SV40 T Ag Antibody (Pab 108) for WB and IHC(P) applications. These reagents are now offered in bundles with SV40 T Ag Antibody (Pab 108) (see ordering information below).
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SV40 T Ag Antibody (Pab 108) is a mouse monoclonal IgG2a kappa light chain antibody that detects SV40 T Ag of SV40 origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-SV40 T Ag antibody (Pab 108) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SV40 T antigen plays a crucial role in the viral life cycle and is essential for the transformation of host cells, as SV40 T antigen interacts with key cellular proteins that regulate cell growth and division. Notably, SV40 large T antigen binds to the retinoblastoma (Rb) tumor suppressor protein, specifically targeting its "pocket" domain, which is also the binding site for the E2F transcription factor. This interaction leads to the inactivation of Rb, thereby releasing E2F and promoting the transcription of genes necessary for cell cycle progression. The ability of SV40 T antigen to disrupt normal cell cycle regulation underscores its importance in studies of oncogenesis and cellular transformation, making SV40 T Ag monoclonal antibody (Pab 108) a valuable tool for researchers investigating the mechanisms of cancer development and viral pathogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SV40 T Ag Antibody (Pab 108) | sc-148 | 200 µg/ml | $316.00 | |||
SV40 T Ag Antibody (Pab 108): m-IgG Fc BP-HRP Bundle | sc-525420 | 200 µg Ab; 10 µg BP | $354.00 | |||
SV40 T Ag Antibody (Pab 108): m-IgG2a BP-HRP Bundle | sc-546244 | 200 µg Ab; 10 µg BP | $354.00 | |||
SV40 T Ag Antibody (Pab 108) AC | sc-148 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SV40 T Ag Antibody (Pab 108) HRP | sc-148 HRP | 200 µg/ml | $316.00 | |||
SV40 T Ag Antibody (Pab 108) FITC | sc-148 FITC | 200 µg/ml | $330.00 | |||
SV40 T Ag Antibody (Pab 108) PE | sc-148 PE | 200 µg/ml | $343.00 | |||
SV40 T Ag Antibody (Pab 108) Alexa Fluor® 488 | sc-148 AF488 | 200 µg/ml | $357.00 | |||
SV40 T Ag Antibody (Pab 108) Alexa Fluor® 546 | sc-148 AF546 | 200 µg/ml | $357.00 | |||
SV40 T Ag Antibody (Pab 108) Alexa Fluor® 594 | sc-148 AF594 | 200 µg/ml | $357.00 | |||
SV40 T Ag Antibody (Pab 108) Alexa Fluor® 647 | sc-148 AF647 | 200 µg/ml | $357.00 | |||
SV40 T Ag Antibody (Pab 108) Alexa Fluor® 680 | sc-148 AF680 | 200 µg/ml | $357.00 | |||
SV40 T Ag Antibody (Pab 108) Alexa Fluor® 790 | sc-148 AF790 | 200 µg/ml | $357.00 |